Matches in SemOpenAlex for { <https://semopenalex.org/work/W1490277622> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1490277622 endingPage "53" @default.
- W1490277622 startingPage "36" @default.
- W1490277622 abstract "One of five Epstein-Barr virus (EBV)-converted sublines of an EBV-negative Burkitt's lymphoma line (BL-41) was identified as a non-tumorigenic phenotypic revertant with low clonability, comparable to that of an EBV-transformed lymphoblastoid cell line (IARC-171) derived from the same patient. This revertant subline (BL41/95) also showed the most LCL-like phenotype of the five convertants tested. It is suggested that reversion was due to the phenotypic shift of the cell from a ‘window’ of cell ontogeny that contains virgin B cells and memory B cells to the stage of the activated immunoblast. Constitutive activation of the c-myc gene by translocation to an immunoglobulin locus continues to drive proliferation of B cells in vivo even after they have undergone a programmed switch to a basically resting (virgin or memory cell) phenotype. An activated immunoblast invariably expresses c-myc. It is also suggested that proliferation of the activated immunoblast is regulated by negative host controls that prevent clonal overexpansion and keep the B cell pool constant. The sensitivity of the immunoblast to this control overrides the ‘forward-driving’ force of both EBV and the activated myc gene." @default.
- W1490277622 created "2016-06-24" @default.
- W1490277622 creator A5051391047 @default.
- W1490277622 date "2007-09-28" @default.
- W1490277622 modified "2023-10-12" @default.
- W1490277622 title "Reversion of Tumorigenicity in An EBV-Converted Burkitt's Lymphoma Line" @default.
- W1490277622 cites W1966697829 @default.
- W1490277622 cites W1973061854 @default.
- W1490277622 cites W1973065685 @default.
- W1490277622 cites W1973298089 @default.
- W1490277622 cites W1980443068 @default.
- W1490277622 cites W1980930194 @default.
- W1490277622 cites W1998912267 @default.
- W1490277622 cites W2000692697 @default.
- W1490277622 cites W2003240475 @default.
- W1490277622 cites W2015012805 @default.
- W1490277622 cites W2015221134 @default.
- W1490277622 cites W2019440005 @default.
- W1490277622 cites W2035487248 @default.
- W1490277622 cites W2039050546 @default.
- W1490277622 cites W2039402804 @default.
- W1490277622 cites W2040069287 @default.
- W1490277622 cites W2060273300 @default.
- W1490277622 cites W2060940529 @default.
- W1490277622 cites W2062002102 @default.
- W1490277622 cites W2075326466 @default.
- W1490277622 cites W2075892339 @default.
- W1490277622 cites W2093528623 @default.
- W1490277622 cites W2095650117 @default.
- W1490277622 cites W2113563899 @default.
- W1490277622 cites W2124147502 @default.
- W1490277622 cites W2192778188 @default.
- W1490277622 cites W4245792082 @default.
- W1490277622 doi "https://doi.org/10.1002/9780470513750.ch4" @default.
- W1490277622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2545422" @default.
- W1490277622 hasPublicationYear "2007" @default.
- W1490277622 type Work @default.
- W1490277622 sameAs 1490277622 @default.
- W1490277622 citedByCount "2" @default.
- W1490277622 crossrefType "book-chapter" @default.
- W1490277622 hasAuthorship W1490277622A5051391047 @default.
- W1490277622 hasConcept C104317684 @default.
- W1490277622 hasConcept C113842279 @default.
- W1490277622 hasConcept C127716648 @default.
- W1490277622 hasConcept C153911025 @default.
- W1490277622 hasConcept C159047783 @default.
- W1490277622 hasConcept C159654299 @default.
- W1490277622 hasConcept C16232356 @default.
- W1490277622 hasConcept C203014093 @default.
- W1490277622 hasConcept C2522874641 @default.
- W1490277622 hasConcept C2778453870 @default.
- W1490277622 hasConcept C2779338263 @default.
- W1490277622 hasConcept C2781375147 @default.
- W1490277622 hasConcept C502942594 @default.
- W1490277622 hasConcept C54355233 @default.
- W1490277622 hasConcept C70883133 @default.
- W1490277622 hasConcept C81885089 @default.
- W1490277622 hasConcept C86803240 @default.
- W1490277622 hasConceptScore W1490277622C104317684 @default.
- W1490277622 hasConceptScore W1490277622C113842279 @default.
- W1490277622 hasConceptScore W1490277622C127716648 @default.
- W1490277622 hasConceptScore W1490277622C153911025 @default.
- W1490277622 hasConceptScore W1490277622C159047783 @default.
- W1490277622 hasConceptScore W1490277622C159654299 @default.
- W1490277622 hasConceptScore W1490277622C16232356 @default.
- W1490277622 hasConceptScore W1490277622C203014093 @default.
- W1490277622 hasConceptScore W1490277622C2522874641 @default.
- W1490277622 hasConceptScore W1490277622C2778453870 @default.
- W1490277622 hasConceptScore W1490277622C2779338263 @default.
- W1490277622 hasConceptScore W1490277622C2781375147 @default.
- W1490277622 hasConceptScore W1490277622C502942594 @default.
- W1490277622 hasConceptScore W1490277622C54355233 @default.
- W1490277622 hasConceptScore W1490277622C70883133 @default.
- W1490277622 hasConceptScore W1490277622C81885089 @default.
- W1490277622 hasConceptScore W1490277622C86803240 @default.
- W1490277622 hasLocation W14902776221 @default.
- W1490277622 hasLocation W14902776222 @default.
- W1490277622 hasOpenAccess W1490277622 @default.
- W1490277622 hasPrimaryLocation W14902776221 @default.
- W1490277622 hasRelatedWork W146697290 @default.
- W1490277622 hasRelatedWork W1977310711 @default.
- W1490277622 hasRelatedWork W2009609503 @default.
- W1490277622 hasRelatedWork W2009749110 @default.
- W1490277622 hasRelatedWork W2022294299 @default.
- W1490277622 hasRelatedWork W2069665018 @default.
- W1490277622 hasRelatedWork W2155445572 @default.
- W1490277622 hasRelatedWork W2312663708 @default.
- W1490277622 hasRelatedWork W2372892891 @default.
- W1490277622 hasRelatedWork W2412961375 @default.
- W1490277622 isParatext "false" @default.
- W1490277622 isRetracted "false" @default.
- W1490277622 magId "1490277622" @default.
- W1490277622 workType "book-chapter" @default.