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• W1490349565 abstract "Plasma LDL-C level is the most well established risk factor for coronary heart disease (CHD) (1). Accordingly, the numerous studies have shown that the LDL-C lowering drugs, statins significantly reduced plasma LDL-C together with approximately 30% reduction in cardiovascular events (2). Therefore, it has been generally believed that the cardiovascular events are directly associated with the elevated LDL-C or its modified oxidized LDL (3). In this manuscript, we have reviewed the patho-physiological role of LDL-C and remnant lipoproteins at cardiovascular events in Japanese sudden cardiac death (SCD) cases (Table 1), especially in SCD cases with nearly normal coronary arteries (coronary atherosclerosis grade (-) and (±), namely Pokkuri Death Syndrome (PDS). As the formation and physiological role of LDL in liver and plasma has been well established, those of remnant lipoproteins (RLP) have also been established recently as a risk for CHD (4-6). As shown in Figure 1, TG-rich lipoprotein (TRL) remnants are formed in the circulation when apoB-48 containing chylomicrons (CM) of intestinal origin or apoB-100 containing VLDL of hepatic origin are converted by lipoprotein lipase (and to a lesser extent by hepatic lipase) into smaller and denser particles of LDL. Compared with their nascent precursors, TRL remnants are depleted of triglycerides, phospholipids, apoA-I and apoA-IV in the case of CM and are enriched in cholesteryl esters, apoCs and apoE (6). They can thus be identified, separated, or quantified in plasma on the basis of their density, charge, size, specific lipid components, apolipoprotein composition and apolipoprotein immunospecificity. This should mean that we have now two identified cardiovascular risk factors, LDL and RLP (CM remnants and VLDL remnants) (Figure 1), in SCD and PDS cases and attempted to understand the differences in their contributions to CHD." @default.
• W1490349565 created "2016-06-24" @default.
• W1490349565 creator A5046326191 @default.
• W1490349565 creator A5052282738 @default.
• W1490349565 date "2012-03-21" @default.
• W1490349565 modified "2023-09-26" @default.
• W1490349565 title "Remnant Lipoproteins are a Stronger Risk Factor for Cardiovascular Events than LDL-C - From the Studies of Autopsies in Sudden Cardiac Death Cases" @default.
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• W1490349565 doi "https://doi.org/10.5772/32221" @default.
• W1490349565 hasPublicationYear "2012" @default.
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