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- W1490405355 abstract "Medullary thyroid carcinoma (MTC), an uncommon neoplasm stemming from the calcitonin-producing thyroid parafollicular C cells, accounts for approximately 3% to 5% of cases of thyroid cancer. Unique among all types of thyroid cancer is the strong association of MTC with inherited tumor syndromes in approximately 20% of cases. The molecular basis of inherited MTC remained obscure until two groups provided evidence that a susceptibility locus for inherited MTC was located on human chromosome 10 (1,2). In 1993, Mulligan and colleagues (3),as well as several other groups (4,5), discovered that characteristic mutations in the ret protooncogene were responsible for the inherited forms of MTC. This seminal finding has had a tremendous impact on the clinical diagnostic evaluation of MTC and continues to shape the direction of research in MTC biology." @default.
- W1490405355 created "2016-06-24" @default.
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- W1490405355 date "2000-01-01" @default.
- W1490405355 modified "2023-09-25" @default.
- W1490405355 title "Medullary Thyroid Carcinoma" @default.
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- W1490405355 doi "https://doi.org/10.1007/978-1-59259-199-2_42" @default.
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