FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1490442871> ?p ?o ?g. }

• W1490442871 endingPage "9" @default.
• W1490442871 startingPage "4072" @default.
• W1490442871 abstract "Nuclear magnetic resonance microimaging measurements of the self-diffusion coefficient of water in large (greater than 2 mm) EMT-6 multicellular spheroids were performed in order to elucidate diffusion mechanisms in tumors. Pulsed gradient spin echo-imaging methods were developed for measuring diffusion in an intravoxel multicompartment system. The self-diffusion coefficient (at 22 degrees C) for water in the medium (Dm) consisted of only a single diffusion compartment [Dm = 1.99 +/- 0.03 (SE) x 10(-5) cm2/s]. Similarly, the spheroid necrotic center showed a single water diffusion compartment with a self-diffusion coefficient (Dc) significantly lower than that of the medium (Dc = 1.54 +/- 0.05 x 10(-5) cm2/s). The spheroid viable rim region showed two distinct compartments of approximately equal volume, one with a large diffusion coefficient (1.70 +/- 0.12 x 10(-5) cm2/s) and a second with a significantly smaller diffusion coefficient (0.25 +/- 0.01 x 10(-5) cm2/s). We propose that these two experimentally distinguishable compartments correspond to the extra- and intracellular regions, respectively, of the viable rim of the spheroid. Although the diffusion coefficients were significantly different in the medium, the necrotic center, and the viable rim, the activation energy for diffusion was the same in the three regions (0.20 eV). Studies of perfused spheroids at 37 degrees C show the same dependence of the diffusion coefficients on the diffusion filter as observed for unperfused spheroids at 22 degrees C. These results demonstrate the ability of nuclear magnetic resonance microimaging to investigate diffusion at the cellular level, which will lead to a better understanding of microenvironmental regulation in tumors." @default.
• W1490442871 created "2016-06-24" @default.
• W1490442871 creator A5034342968 @default.
• W1490442871 creator A5041869508 @default.
• W1490442871 creator A5068038990 @default.
• W1490442871 creator A5087074978 @default.
• W1490442871 date "1991-08-01" @default.
• W1490442871 modified "2023-10-16" @default.
• W1490442871 title "Self-diffusion of water in multicellular spheroids measured by magnetic resonance microimaging." @default.
• W1490442871 cites W1639123716 @default.
• W1490442871 cites W1969291097 @default.
• W1490442871 cites W1972081739 @default.
• W1490442871 cites W1972676624 @default.
• W1490442871 cites W1979053998 @default.
• W1490442871 cites W1981717673 @default.
• W1490442871 cites W1990096946 @default.
• W1490442871 cites W1993337346 @default.
• W1490442871 cites W2001284321 @default.
• W1490442871 cites W2005490230 @default.
• W1490442871 cites W2008017388 @default.
• W1490442871 cites W2011412251 @default.
• W1490442871 cites W2012524626 @default.
• W1490442871 cites W2015475492 @default.
• W1490442871 cites W2015536104 @default.
• W1490442871 cites W2033628588 @default.
• W1490442871 cites W2041765511 @default.
• W1490442871 cites W2044711624 @default.
• W1490442871 cites W2048430791 @default.
• W1490442871 cites W2049223989 @default.
• W1490442871 cites W2054116704 @default.
• W1490442871 cites W2054130199 @default.
• W1490442871 cites W2068860991 @default.
• W1490442871 cites W2077759492 @default.
• W1490442871 cites W2079639684 @default.
• W1490442871 cites W2084761689 @default.
• W1490442871 cites W2089026118 @default.
• W1490442871 cites W2093080620 @default.
• W1490442871 cites W2128440389 @default.
• W1490442871 cites W2129841144 @default.
• W1490442871 cites W2148915909 @default.
• W1490442871 cites W2152004539 @default.
• W1490442871 cites W2154492417 @default.
• W1490442871 cites W2166159513 @default.
• W1490442871 cites W2731900469 @default.
• W1490442871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1855222" @default.
• W1490442871 hasPublicationYear "1991" @default.
• W1490442871 type Work @default.
• W1490442871 sameAs 1490442871 @default.
• W1490442871 citedByCount "13" @default.
• W1490442871 countsByYear W14904428712017 @default.
• W1490442871 crossrefType "journal-article" @default.
• W1490442871 hasAuthorship W1490442871A5034342968 @default.
• W1490442871 hasAuthorship W1490442871A5041869508 @default.
• W1490442871 hasAuthorship W1490442871A5068038990 @default.
• W1490442871 hasAuthorship W1490442871A5087074978 @default.
• W1490442871 hasConcept C113196181 @default.
• W1490442871 hasConcept C121332964 @default.
• W1490442871 hasConcept C12554922 @default.
• W1490442871 hasConcept C126838900 @default.
• W1490442871 hasConcept C143409427 @default.
• W1490442871 hasConcept C175369904 @default.
• W1490442871 hasConcept C185592680 @default.
• W1490442871 hasConcept C192562407 @default.
• W1490442871 hasConcept C202751555 @default.
• W1490442871 hasConcept C43617362 @default.
• W1490442871 hasConcept C46141821 @default.
• W1490442871 hasConcept C55493867 @default.
• W1490442871 hasConcept C69357855 @default.
• W1490442871 hasConcept C70816921 @default.
• W1490442871 hasConcept C71924100 @default.
• W1490442871 hasConcept C83042744 @default.
• W1490442871 hasConcept C86803240 @default.
• W1490442871 hasConcept C97355855 @default.
• W1490442871 hasConceptScore W1490442871C113196181 @default.
• W1490442871 hasConceptScore W1490442871C121332964 @default.
• W1490442871 hasConceptScore W1490442871C12554922 @default.
• W1490442871 hasConceptScore W1490442871C126838900 @default.
• W1490442871 hasConceptScore W1490442871C143409427 @default.
• W1490442871 hasConceptScore W1490442871C175369904 @default.
• W1490442871 hasConceptScore W1490442871C185592680 @default.
• W1490442871 hasConceptScore W1490442871C192562407 @default.
• W1490442871 hasConceptScore W1490442871C202751555 @default.
• W1490442871 hasConceptScore W1490442871C43617362 @default.
• W1490442871 hasConceptScore W1490442871C46141821 @default.
• W1490442871 hasConceptScore W1490442871C55493867 @default.
• W1490442871 hasConceptScore W1490442871C69357855 @default.
• W1490442871 hasConceptScore W1490442871C70816921 @default.
• W1490442871 hasConceptScore W1490442871C71924100 @default.
• W1490442871 hasConceptScore W1490442871C83042744 @default.
• W1490442871 hasConceptScore W1490442871C86803240 @default.
• W1490442871 hasConceptScore W1490442871C97355855 @default.
• W1490442871 hasIssue "15" @default.
• W1490442871 hasLocation W14904428711 @default.
• W1490442871 hasOpenAccess W1490442871 @default.
• W1490442871 hasPrimaryLocation W14904428711 @default.
• W1490442871 hasRelatedWork W1490442871 @default.
• W1490442871 hasRelatedWork W1749546866 @default.
• W1490442871 hasRelatedWork W1968710739 @default.

• next