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• W1490477370 abstract "Bacterial pathogens are the major cause of mortality across the globe, as current use of antibiotics and vaccines is unable to prevent the spread of bacterial pathogens. Rapid evolution allowed bacteria to overcome the hostile environmental conditions. Survival strategies, such as, biofilm formation, stringent response, sporulation, cyst formation and horizontal transfer of resistance genes have made it even more difficult to treat the bacterial disease. Rate of bacterial evolution has subdued the pace of discovery of new antibiotics. Most of the antibiotics target the lag and log phases of bacterial growth. It is realized that for complete omission of bacterial pathogens, survival strategies have to be restricted. Under stress, bacteria give rise to stringent response which initiates various signalling cascades escalating the activation of different survival strategies, including biofilm formation. Synthetic glycolipids and (p)ppGpp analogs hold promise to potential therapeutics for impeding the survival strategies. We have noticed earlier that various analogs of stringent response modulator (p)ppGpp hold promise for therapeutic intervention during stress. In addition, several small molecules, which are overproduced during biofilm formation, may also be targeted. In this article, such attempts are discussed." @default.
• W1490477370 created "2016-06-24" @default.
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• W1490477370 date "2014-11-03" @default.
• W1490477370 modified "2023-09-27" @default.
• W1490477370 title "Synthetic Glycolipids and (p)ppGpp Analogs: Development of Inhibitors for Mycobacterial Growth, Biofilm and Stringent Response" @default.
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• W1490477370 doi "https://doi.org/10.1007/978-3-319-11280-0_20" @default.
• W1490477370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25408352" @default.
• W1490477370 hasPublicationYear "2014" @default.
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