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- W1490487906 abstract "Many human malignancies lack de novo biosynthesis of arginine (Arg) as the key enzyme argininosuccinate synthetase 1 (ASS1) is silenced. These tumors acquire ectopic Arg for survival, and depleting this source by Arg-depleting recombinant enzyme ADI-PEG20 results in cell death. Mechanisms underlying Arg auxotrophy in these tumors and how they respond to Arg-auxotrophic stress are poorly understood. Here, we report that an immediate-early event of Arg-auxotrophic response involves reactive oxygen species-mediated secretion of Gas6, which interacts with its receptor Axl and activates the downstream Ras/PI3K/Akt growth signal leading to accumulation of c-Myc by protein stabilization. Arg-auxotrophic challenge also transcriptionally upregulates c-Myc expression, which provides a feedback mechanism to enhance Axl expression. c-Myc is a positive regulator of ASS1, but elevated ASS1 provides a feedback mechanism to suppress c-Myc and Axl. Our results revealed multiple inter-regulatory pathways in Arg-auxotrophic response, consisting of Axl, c-Myc and ASS1, which regulate Arg homeostasis and ADI-PEG20 sensitivity. These pathways provide potential targets for improving the efficacy of treating Arg-auxotrophic tumors using Arg-deprivation strategies." @default.
- W1490487906 created "2016-06-24" @default.
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- W1490487906 date "2015-06-22" @default.
- W1490487906 modified "2023-10-05" @default.
- W1490487906 title "Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents" @default.
- W1490487906 cites W127753390 @default.
- W1490487906 cites W141200506 @default.
- W1490487906 cites W1569238414 @default.
- W1490487906 cites W1941646742 @default.
- W1490487906 cites W1946393004 @default.
- W1490487906 cites W1963604934 @default.
- W1490487906 cites W1969346834 @default.
- W1490487906 cites W1971602395 @default.
- W1490487906 cites W1974380503 @default.
- W1490487906 cites W1976395092 @default.
- W1490487906 cites W1977527100 @default.
- W1490487906 cites W1983774108 @default.
- W1490487906 cites W1985786752 @default.
- W1490487906 cites W1987848307 @default.
- W1490487906 cites W1990973079 @default.
- W1490487906 cites W1999494567 @default.
- W1490487906 cites W2003445065 @default.
- W1490487906 cites W2004071564 @default.
- W1490487906 cites W2005816180 @default.
- W1490487906 cites W2008239768 @default.
- W1490487906 cites W2008410413 @default.
- W1490487906 cites W2009129162 @default.
- W1490487906 cites W2013022837 @default.
- W1490487906 cites W2013206354 @default.
- W1490487906 cites W2031599457 @default.
- W1490487906 cites W2033556277 @default.
- W1490487906 cites W2035671754 @default.
- W1490487906 cites W2036571449 @default.
- W1490487906 cites W2044811151 @default.
- W1490487906 cites W2046142904 @default.
- W1490487906 cites W2057796192 @default.
- W1490487906 cites W2058133637 @default.
- W1490487906 cites W2062581217 @default.
- W1490487906 cites W2062714569 @default.
- W1490487906 cites W2065261951 @default.
- W1490487906 cites W2071146934 @default.
- W1490487906 cites W2083870593 @default.
- W1490487906 cites W2085213714 @default.
- W1490487906 cites W2087167227 @default.
- W1490487906 cites W2087807120 @default.
- W1490487906 cites W2087900616 @default.
- W1490487906 cites W2088665501 @default.
- W1490487906 cites W2094548766 @default.
- W1490487906 cites W2098094939 @default.
- W1490487906 cites W2098673687 @default.
- W1490487906 cites W2103004313 @default.
- W1490487906 cites W2106712645 @default.
- W1490487906 cites W2107376500 @default.
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- W1490487906 cites W2140178643 @default.
- W1490487906 cites W2141674733 @default.
- W1490487906 cites W2141948588 @default.
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- W1490487906 cites W2159290008 @default.
- W1490487906 cites W2160249387 @default.
- W1490487906 cites W2169105660 @default.
- W1490487906 cites W2171506809 @default.
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- W1490487906 doi "https://doi.org/10.1038/onc.2015.237" @default.
- W1490487906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4835044" @default.
- W1490487906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26096933" @default.
- W1490487906 hasPublicationYear "2015" @default.
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