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• W149048954 abstract "ABSTRACT Auto-immunity at the level of anti-idiotypes is able at both the humoral and cellular level to enhance or inhibit specific immune responses. The very same agent may depending upon external conditions cause a positive or negative impact on a particular immune reaction. Subgroups of T lyrrphocytes specific forallo-MHC antigens can be shown to display distinctly different idiotypes. This may allow interactions between T cell subsets for reasons of anti-idiotypic reactions rather than via collaboration through reactions against antigenic determinants present on the same molecule or particle. Earlier work showing enhancing ability of IgM antibodies for sheep erythrocytes when passively administered to recipients receiving sub-optimal doses of immunogen may also in part function via auto-immune, idiotypic interactions. In the system of allo-MHC reactions auto-anti-idiotypic immunity can provide a tool for induction of specific unresponsiveness in an adult, immunocompetent individual. Problems still to be resolved before this approach can be used in the clinic are discussed. Finally, purified internally labelled single chains of rat MHC type (heavy chain Ag-B and heavy and light chain “Ia” molecules) were tested for binding abilities to immunosorbants made up of IgG allo-antibody molecules or T cell derived molecules selected for idiotypic markers signifying reactivity against a particular allo-MHC haplotype. In the combination analyzed (Lewis-anti-DA) the allo-antibody immunosorbant columns could be shown to retain all three DA chains (= each chain must display alloantigenic variability) whilst failing to show binding to syngeneic Lewis or third party BN MHC molecules. On the other hand, the idiotypic “Lewis-anti-DA” immunosorbant constructed from normal T cell derived molecules displayed binding for three chains: Ag-B and Ia heavy chains of DA origin (= strongly bound) and syngeneic Lewis heavy Ia chain (= weakly bound). The fact that BN chains failed to express any detectable binding proved that normal, unimmunized T cells are indeed selected for specific binding ability for self-MHC determinants. Furthermore, as the idiotypic T cell molecules all display strong binding ability for DA spleen cells whilst at the same time expressing measurable anti-self-MHC reactivity one would have to conclude that allo-reactive T cells can also react towards self-MHC determinants using the very same receptor molecules." @default.
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• W149048954 date "1979-01-01" @default.
• W149048954 modified "2023-10-04" @default.
• W149048954 title "SPECIFIC AUTO-IMMUNITY DURING THE IMMUNE RESPONSE: IDIOTYPES AND ANTIGEN-BINDING SPECIFICITY OF ANTI-BODIES AND T CELL RECEPTORS" @default.
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• W149048954 doi "https://doi.org/10.1016/b978-0-12-069850-9.50052-3" @default.
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