Matches in SemOpenAlex for { <https://semopenalex.org/work/W1490491630> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1490491630 endingPage "204" @default.
- W1490491630 startingPage "199" @default.
- W1490491630 abstract "By applying invasive techniques for direct measurements of oxygen tension, we have reported decreased kidney oxygenation in experimental diabetes in rats. However, the non-invasive MRI technique utilizing the BOLD effect provides several advantages with the possibility to perform repetitive measurements in the same animals and in human subjects. In this study, we applied a modified single gradient echo microimaging sequence to detect the BOLD effect in kidneys of diabetic rats and compared the results to normoglycemic controls. All measurements were performed on inactin-anaesthetized adult male Wistar Furth rats. Diabetes was induced by streptozotocin (45 mg/kg) 14 days prior to MRI-analysis. Sixteen T2*-weighted image records (B0=1.5 T) were performed using radiofrequency spoiled gradient echo sequence with 2.6 ms step increments of TE (TE1=12 ms), while TR (75 ms) and bandwidth per pixel (71.4 Hz) were kept constant. T2* maps were computed by mono-exponential fitting of the pixel intensities. Relaxation rates R2* (1/T2*) in cortex and outer stripe of the outer medulla were similar in both groups (cortex for controls 22.3±0.4 vs. diabetics 23.1±1.8 Hz and outer stripe of outer medulla for controls 24.9±0.4 vs. diabetics 26.4±1.8 Hz; n=4 in both groups), whereas R2* was increased in the inner stripe of the outer medulla in diabetic rats (diabetics 26.1±2.4 vs. controls 18.8±1.4 Hz; n=4, P<0.05). This study demonstrates that experimental diabetes in rats induces decreased oxygenation of the renal outer medulla. Furthermore, the proposed T2*-weighted MR micro-imaging technique is suitable for detection of regional changes in kidney oxygenation in experimental animal models." @default.
- W1490491630 created "2016-06-24" @default.
- W1490491630 creator A5018397837 @default.
- W1490491630 creator A5025388780 @default.
- W1490491630 creator A5035653406 @default.
- W1490491630 creator A5036967624 @default.
- W1490491630 creator A5037172010 @default.
- W1490491630 creator A5048037390 @default.
- W1490491630 creator A5070454451 @default.
- W1490491630 date "2009-01-01" @default.
- W1490491630 modified "2023-10-13" @default.
- W1490491630 title "Reduced Oxygenation In Diabetic Rat Kidneys Measured By T2* Weighted Magnetic Resonance Micro-Imaging" @default.
- W1490491630 cites W1964981722 @default.
- W1490491630 cites W1993257229 @default.
- W1490491630 cites W1995544868 @default.
- W1490491630 cites W1998665848 @default.
- W1490491630 cites W2033709073 @default.
- W1490491630 cites W2035637304 @default.
- W1490491630 cites W2052947477 @default.
- W1490491630 cites W2053711278 @default.
- W1490491630 cites W2118316104 @default.
- W1490491630 cites W2147857276 @default.
- W1490491630 doi "https://doi.org/10.1007/978-0-387-85998-9_31" @default.
- W1490491630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19227472" @default.
- W1490491630 hasPublicationYear "2009" @default.
- W1490491630 type Work @default.
- W1490491630 sameAs 1490491630 @default.
- W1490491630 citedByCount "29" @default.
- W1490491630 countsByYear W14904916302012 @default.
- W1490491630 countsByYear W14904916302013 @default.
- W1490491630 countsByYear W14904916302014 @default.
- W1490491630 countsByYear W14904916302016 @default.
- W1490491630 countsByYear W14904916302017 @default.
- W1490491630 countsByYear W14904916302018 @default.
- W1490491630 countsByYear W14904916302019 @default.
- W1490491630 countsByYear W14904916302020 @default.
- W1490491630 countsByYear W14904916302021 @default.
- W1490491630 countsByYear W14904916302022 @default.
- W1490491630 crossrefType "book-chapter" @default.
- W1490491630 hasAuthorship W1490491630A5018397837 @default.
- W1490491630 hasAuthorship W1490491630A5025388780 @default.
- W1490491630 hasAuthorship W1490491630A5035653406 @default.
- W1490491630 hasAuthorship W1490491630A5036967624 @default.
- W1490491630 hasAuthorship W1490491630A5037172010 @default.
- W1490491630 hasAuthorship W1490491630A5048037390 @default.
- W1490491630 hasAuthorship W1490491630A5070454451 @default.
- W1490491630 hasConcept C105702510 @default.
- W1490491630 hasConcept C121332964 @default.
- W1490491630 hasConcept C126322002 @default.
- W1490491630 hasConcept C126838900 @default.
- W1490491630 hasConcept C134018914 @default.
- W1490491630 hasConcept C143409427 @default.
- W1490491630 hasConcept C17291353 @default.
- W1490491630 hasConcept C185592680 @default.
- W1490491630 hasConcept C2779280383 @default.
- W1490491630 hasConcept C2780091579 @default.
- W1490491630 hasConcept C46141821 @default.
- W1490491630 hasConcept C555293320 @default.
- W1490491630 hasConcept C70289976 @default.
- W1490491630 hasConcept C71924100 @default.
- W1490491630 hasConceptScore W1490491630C105702510 @default.
- W1490491630 hasConceptScore W1490491630C121332964 @default.
- W1490491630 hasConceptScore W1490491630C126322002 @default.
- W1490491630 hasConceptScore W1490491630C126838900 @default.
- W1490491630 hasConceptScore W1490491630C134018914 @default.
- W1490491630 hasConceptScore W1490491630C143409427 @default.
- W1490491630 hasConceptScore W1490491630C17291353 @default.
- W1490491630 hasConceptScore W1490491630C185592680 @default.
- W1490491630 hasConceptScore W1490491630C2779280383 @default.
- W1490491630 hasConceptScore W1490491630C2780091579 @default.
- W1490491630 hasConceptScore W1490491630C46141821 @default.
- W1490491630 hasConceptScore W1490491630C555293320 @default.
- W1490491630 hasConceptScore W1490491630C70289976 @default.
- W1490491630 hasConceptScore W1490491630C71924100 @default.
- W1490491630 hasLocation W14904916301 @default.
- W1490491630 hasLocation W14904916302 @default.
- W1490491630 hasOpenAccess W1490491630 @default.
- W1490491630 hasPrimaryLocation W14904916301 @default.
- W1490491630 hasRelatedWork W1978038050 @default.
- W1490491630 hasRelatedWork W2007234183 @default.
- W1490491630 hasRelatedWork W2023460452 @default.
- W1490491630 hasRelatedWork W2056068477 @default.
- W1490491630 hasRelatedWork W2059410790 @default.
- W1490491630 hasRelatedWork W2114227454 @default.
- W1490491630 hasRelatedWork W2182404185 @default.
- W1490491630 hasRelatedWork W2378100379 @default.
- W1490491630 hasRelatedWork W2409779263 @default.
- W1490491630 hasRelatedWork W4360619282 @default.
- W1490491630 isParatext "false" @default.
- W1490491630 isRetracted "false" @default.
- W1490491630 magId "1490491630" @default.
- W1490491630 workType "book-chapter" @default.