FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1490502914> ?p ?o ?g. }

• W1490502914 endingPage "240" @default.
• W1490502914 startingPage "229" @default.
• W1490502914 abstract "Accumulating evidence indicates that immune impairment in persistent viral infections could lead to T-cell exhaustion. To evaluate the potential contribution of induction of negative costimulatory molecules to impaired T-cell responses, we primed naïve T cells with mature monocyte-derived dendritic cells (MDDCs) pulsed with HIV-1 in vitro. We used quantitative real-time polymerase chain reaction and flow cytometry, respectively, to compare the gene and surface-protein expression profiles of naïve T cells primed with HIV-pulsed or mock-pulsed DCs. We detected elevated expressions of negative costimulatory molecules, including lymphocyte activation gene-3 (LAG-3), CD160, cytolytic T-lymphocyte antigen-4 (CTLA-4), T-cell immunoglobulin mucincontaining domain-3 (TIM-3), programmed death-1 (PD-1) and TRAIL (tumor necrosis-factor-related apoptosis-inducing ligand) in T cells primed by HIV-pulsed DCs. The PD-1+ T-cell population also coexpressed TIM-3, LAG-3, and CTLA-4. Interestingly, we also found an increase in gene expression of the transcriptional repressors Blimp-1 (B-lymphocyte-induced maturation protein-1) and Foxp3 (forkhead transcription factor) in T-cells primed by HIV-pulsed DCs; Blimp-1 expression was directly proportional to the expression of the negative costimulatory molecules. Furthermore, levels of the effector cytokines interleukin-2, tumor necrosis factor-α and interferon-γ, and perforin and granzyme B were decreased in T-cell populations primed by HIV-pulsed DCs. In conclusion, in vitro priming of naïve T-cells with HIV-pulsed DC leads to expansion of T cells with coexpression of a broad array of negative costimulatory molecules and Blimp-1, with potential deleterious consequences for T-cell responses." @default.
• W1490502914 created "2016-06-24" @default.
• W1490502914 creator A5025226467 @default.
• W1490502914 creator A5042801011 @default.
• W1490502914 creator A5043225490 @default.
• W1490502914 creator A5080851422 @default.
• W1490502914 creator A5089710137 @default.
• W1490502914 date "2010-11-17" @default.
• W1490502914 modified "2023-10-15" @default.
• W1490502914 title "Expression of a Broad Array of Negative Costimulatory Molecules and Blimp-1 in T Cells following Priming by HIV-1 Pulsed Dendritic Cells" @default.
• W1490502914 cites W1479904733 @default.
• W1490502914 cites W1513178664 @default.
• W1490502914 cites W1542616270 @default.
• W1490502914 cites W1557952727 @default.
• W1490502914 cites W1567942516 @default.
• W1490502914 cites W1801247541 @default.
• W1490502914 cites W1915271695 @default.
• W1490502914 cites W1965240376 @default.
• W1490502914 cites W1968276891 @default.
• W1490502914 cites W1975346956 @default.
• W1490502914 cites W1977652214 @default.
• W1490502914 cites W1978436252 @default.
• W1490502914 cites W1978715924 @default.
• W1490502914 cites W1981431992 @default.
• W1490502914 cites W1984709119 @default.
• W1490502914 cites W1985406652 @default.
• W1490502914 cites W1987337968 @default.
• W1490502914 cites W1988338839 @default.
• W1490502914 cites W1988474688 @default.
• W1490502914 cites W1988941798 @default.
• W1490502914 cites W1992011740 @default.
• W1490502914 cites W1992641327 @default.
• W1490502914 cites W1993002158 @default.
• W1490502914 cites W1993617345 @default.
• W1490502914 cites W2004951070 @default.
• W1490502914 cites W2004998289 @default.
• W1490502914 cites W2018008269 @default.
• W1490502914 cites W2018710900 @default.
• W1490502914 cites W2021379322 @default.
• W1490502914 cites W2026939258 @default.
• W1490502914 cites W2035852466 @default.
• W1490502914 cites W2052855154 @default.
• W1490502914 cites W2053677639 @default.
• W1490502914 cites W2058798829 @default.
• W1490502914 cites W2061492994 @default.
• W1490502914 cites W2061536824 @default.
• W1490502914 cites W2063333949 @default.
• W1490502914 cites W2067939508 @default.
• W1490502914 cites W2070631889 @default.
• W1490502914 cites W2071177946 @default.
• W1490502914 cites W2072380594 @default.
• W1490502914 cites W2079101337 @default.
• W1490502914 cites W2081447339 @default.
• W1490502914 cites W2088541970 @default.
• W1490502914 cites W2092508425 @default.
• W1490502914 cites W2097074610 @default.
• W1490502914 cites W2097855813 @default.
• W1490502914 cites W2099468505 @default.
• W1490502914 cites W2104966044 @default.
• W1490502914 cites W2107322032 @default.
• W1490502914 cites W2108565475 @default.
• W1490502914 cites W2112606808 @default.
• W1490502914 cites W2116015828 @default.
• W1490502914 cites W2118705059 @default.
• W1490502914 cites W2121273824 @default.
• W1490502914 cites W2121632584 @default.
• W1490502914 cites W2122689603 @default.
• W1490502914 cites W2123528481 @default.
• W1490502914 cites W2129701357 @default.
• W1490502914 cites W2130035794 @default.
• W1490502914 cites W2130822830 @default.
• W1490502914 cites W2132926599 @default.
• W1490502914 cites W2135698322 @default.
• W1490502914 cites W2145075050 @default.
• W1490502914 cites W2145091932 @default.
• W1490502914 cites W2145476394 @default.
• W1490502914 cites W2145893204 @default.
• W1490502914 cites W2147132132 @default.
• W1490502914 cites W2152095262 @default.
• W1490502914 cites W2157199182 @default.
• W1490502914 cites W2166300495 @default.
• W1490502914 cites W2168231169 @default.
• W1490502914 cites W2169212859 @default.
• W1490502914 cites W2169394657 @default.
• W1490502914 cites W2171377694 @default.
• W1490502914 cites W2172223853 @default.
• W1490502914 cites W2592935721 @default.
• W1490502914 doi "https://doi.org/10.2119/molmed.2010.00175" @default.
• W1490502914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3060986" @default.
• W1490502914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21103670" @default.
• W1490502914 hasPublicationYear "2010" @default.
• W1490502914 type Work @default.
• W1490502914 sameAs 1490502914 @default.
• W1490502914 citedByCount "56" @default.
• W1490502914 countsByYear W14905029142012 @default.
• W1490502914 countsByYear W14905029142013 @default.
• W1490502914 countsByYear W14905029142014 @default.
• W1490502914 countsByYear W14905029142015 @default.

• next