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- W1490654108 abstract "The most common cause of paediatric end-stage kidney disease results from congenital anomalies of the kidney and urinary tract (CAKUT). Genetic manipulation in mice has provided insight into the developmental events that give rise to the broad spectrum of malformations associated with CAKUT. Despite the increase in the number of identified CAKUT-causing genes, the underlying genetic cause for the majority of patients with CAKUT remains unknown. In this mini-review, we provide an overview of the genetic causes of CAKUT based on current mouse mutant models, as well as next-generation sequencing approaches in humans that are helping to bridge the gaps in our understanding." @default.
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- W1490654108 date "2015-04-15" @default.
- W1490654108 modified "2023-10-14" @default.
- W1490654108 title "Congenital anomalies of the kidney and urinary tract genetics in mice and men" @default.
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- W1490654108 doi "https://doi.org/10.1111/nep.12402" @default.
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