Matches in SemOpenAlex for { <https://semopenalex.org/work/W1490750046> ?p ?o ?g. }
- W1490750046 endingPage "S378" @default.
- W1490750046 startingPage "S367" @default.
- W1490750046 abstract "There is compelling evidence that uncontrolled activation of the coagulation cascade following lung injury contributes to the development of lung inflammation and fibrosis in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) and fibrotic lung disease. This article reviews our current understanding of the mechanisms leading to the activation of the coagulation cascade in response to lung injury and the evidence that excessive procoagulant activity is of pathophysiological significance in these disease settings. Current evidence suggests that the tissue factor-dependent extrinsic pathway is the predominant mechanism by which the coagulation cascade is locally activated in the lungs of patients with ALI/ARDS and pulmonary fibrosis. Whilst, fibrin deposition might contribute to the pathophysiology of ALI/ARDS following systemic insult; current evidence suggests that the cellular effects mediated via activation of proteinase-activated receptors (PARs) may be of particular importance in influencing inflammatory and fibroproliferative responses in experimental models involving direct injury to the lung. In this regard, studies in PAR(1) knockout mice have shown that this receptor plays a major role in orchestrating the interplay between coagulation, inflammation and lung fibrosis. This review will focus on our current understanding of excessive procoagulant signalling in acute and chronic lung injury and will highlight the novel opportunities that this may present for therapeutic intervention." @default.
- W1490750046 created "2016-06-24" @default.
- W1490750046 creator A5075891901 @default.
- W1490750046 date "2008-03-01" @default.
- W1490750046 modified "2023-10-14" @default.
- W1490750046 title "Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention?" @default.
- W1490750046 cites W1480011331 @default.
- W1490750046 cites W17106945 @default.
- W1490750046 cites W1861812628 @default.
- W1490750046 cites W1967294048 @default.
- W1490750046 cites W1967741390 @default.
- W1490750046 cites W1967923997 @default.
- W1490750046 cites W1970301114 @default.
- W1490750046 cites W1971428844 @default.
- W1490750046 cites W1972644785 @default.
- W1490750046 cites W1976569882 @default.
- W1490750046 cites W1978003589 @default.
- W1490750046 cites W1978532495 @default.
- W1490750046 cites W1980358070 @default.
- W1490750046 cites W1981985061 @default.
- W1490750046 cites W1984849676 @default.
- W1490750046 cites W1988036742 @default.
- W1490750046 cites W1992800099 @default.
- W1490750046 cites W2000985786 @default.
- W1490750046 cites W2002994982 @default.
- W1490750046 cites W2005028693 @default.
- W1490750046 cites W2006831350 @default.
- W1490750046 cites W2011831021 @default.
- W1490750046 cites W2011953130 @default.
- W1490750046 cites W2012747631 @default.
- W1490750046 cites W2016120457 @default.
- W1490750046 cites W2019431738 @default.
- W1490750046 cites W2021545596 @default.
- W1490750046 cites W2022178125 @default.
- W1490750046 cites W2027837178 @default.
- W1490750046 cites W2030198326 @default.
- W1490750046 cites W2035667751 @default.
- W1490750046 cites W2038585115 @default.
- W1490750046 cites W2041726150 @default.
- W1490750046 cites W2044266703 @default.
- W1490750046 cites W2044332974 @default.
- W1490750046 cites W2044478331 @default.
- W1490750046 cites W2044561109 @default.
- W1490750046 cites W2045375116 @default.
- W1490750046 cites W2047352816 @default.
- W1490750046 cites W2048279747 @default.
- W1490750046 cites W2048964708 @default.
- W1490750046 cites W2051879911 @default.
- W1490750046 cites W2058252463 @default.
- W1490750046 cites W2060928333 @default.
- W1490750046 cites W2063436562 @default.
- W1490750046 cites W2064545046 @default.
- W1490750046 cites W2070885036 @default.
- W1490750046 cites W2071326163 @default.
- W1490750046 cites W2072884900 @default.
- W1490750046 cites W2073605647 @default.
- W1490750046 cites W2077888205 @default.
- W1490750046 cites W2079377586 @default.
- W1490750046 cites W2081753893 @default.
- W1490750046 cites W2086357056 @default.
- W1490750046 cites W2094158785 @default.
- W1490750046 cites W2096588077 @default.
- W1490750046 cites W2096801164 @default.
- W1490750046 cites W2097036700 @default.
- W1490750046 cites W2097978038 @default.
- W1490750046 cites W2105096946 @default.
- W1490750046 cites W2108664084 @default.
- W1490750046 cites W2110869240 @default.
- W1490750046 cites W2124887937 @default.
- W1490750046 cites W2130104463 @default.
- W1490750046 cites W2133310011 @default.
- W1490750046 cites W2134499077 @default.
- W1490750046 cites W2135599949 @default.
- W1490750046 cites W2136539876 @default.
- W1490750046 cites W2136616179 @default.
- W1490750046 cites W2137035430 @default.
- W1490750046 cites W2138153375 @default.
- W1490750046 cites W2147829277 @default.
- W1490750046 cites W2155956503 @default.
- W1490750046 cites W2156036748 @default.
- W1490750046 cites W2161623759 @default.
- W1490750046 cites W2163086793 @default.
- W1490750046 cites W2166270090 @default.
- W1490750046 cites W2167351713 @default.
- W1490750046 cites W2261467449 @default.
- W1490750046 cites W2266449379 @default.
- W1490750046 doi "https://doi.org/10.1038/sj.bjp.0707603" @default.
- W1490750046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2268072" @default.
- W1490750046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18223674" @default.
- W1490750046 hasPublicationYear "2008" @default.
- W1490750046 type Work @default.
- W1490750046 sameAs 1490750046 @default.
- W1490750046 citedByCount "146" @default.
- W1490750046 countsByYear W14907500462012 @default.
- W1490750046 countsByYear W14907500462013 @default.
- W1490750046 countsByYear W14907500462014 @default.
- W1490750046 countsByYear W14907500462015 @default.
- W1490750046 countsByYear W14907500462016 @default.