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- W1490752890 abstract "PURPOSETo compare diffusion-weighted functional magnetic resonance imaging (DfMRI), a novel alternative to the blood oxygenation level-dependent (BOLD) contrast, in a functional MRI experiment. MATERIALS AND METHODSNine participants viewed contrast reversing (7.5 Hz) black-and-white checkerboard stimuli using block and event-related paradigms. DfMRI (b = 1800 mm/s2 ) and BOLD sequences were acquired. Four parameters describing the observed signal were assessed: percent signal change, spatial extent of the activation, the Euclidean distance between peak voxel locations, and the time-to-peak of the best fitting impulse response for different paradigms and sequences. RESULTSThe BOLD conditions showed a higher percent signal change relative to DfMRI; however, event-related DfMRI showed the strongest group activation (t = 21.23, P < 0.0005). Activation was more diffuse and spatially closer to the BOLD response for DfMRI when the block design was used. DfMRIevent showed the shortest TTP (4.4 +/- 0.88 sec). CONCLUSIONThe hemodynamic contribution to DfMRI may increase with the use of block designs." @default.
- W1490752890 created "2016-06-24" @default.
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- W1490752890 date "2014-01-01" @default.
- W1490752890 modified "2023-09-23" @default.
- W1490752890 title "Comparison of block and event-related experimental designs in diffusion-weighted functional MRI" @default.
- W1490752890 hasPublicationYear "2014" @default.
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