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- W1490756663 abstract "Activating BRAFV600E mutations occur in about 43% of primary melanomas [1]. An early clinical experience with a novel class I RAF-selective inhibitor, vemurafenib, demonstrated an unprecedented 48% antitumor response rate among patients with BRAFV600E-positive melanomas [2].Although vemurafenib sensitizes melanoma cells to irradiation in vitro [3], it has never been tested combined with radiotherapy in a clinical trial. We report dramatic responses to radiotherapy in two patients who exhibited a [...]" @default.
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- W1490756663 date "2014-03-01" @default.
- W1490756663 modified "2023-09-28" @default.
- W1490756663 title "Dramatic response to radiotherapy combined with vemurafenib. Is vemurafenib a radiosensitizer?" @default.
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- W1490756663 doi "https://doi.org/10.1684/ejd.2014.2300" @default.
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