FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1490802923> ?p ?o ?g. }

• W1490802923 abstract "Echis carinatus is one of the venomous snakes in Iran. The venom of Iranian Echis carinatus is a rich source of protein with various factors affecting the plasma protein and blood coagulation factor. Some of these proteins exhibit types of enzymatic activities. However, other items are proteins with no enzymatic activity.In order to study the mechanism and effect of the venom on human plasma proteins, the present study has evaluated the effect of crude venom and all fractions. A procoagulant factor (prothrombin activator) was isolated from the venom of the Iranian snake Echis carinatus with a combination of gel filtration (Sephadex G-75), ion-exchange chromatography (DEAE- Sepharose) and reverse phase HPLC. Furthermore, proteolytic activity of the crude venom and all fractions on blood coagulation factors such as prothrombin time (PT) was studied.In the present study, the PT test was reduced from 13.4 s to 8.6 s when human plasma was treated with crude venom (concentraion of venom was 1 mg/ml). The purified procoagulant factor revealed a single protein band in SDS polyacrylamide electrophoresis under reducing conditions and its molecular weight was estimated at about 65 kDa. A single-band protein showed fragment patterns similar to those generated by the group A prothrombin activators, which convert prothrombin into meizothrombin independent of the prothrombinase complex.This study showed that the fraction which separated from Iranian snake Echis carinatus venom can be a prothrombin activators. It can be concluded that this fraction is a procoagulant factor." @default.
• W1490802923 created "2016-06-24" @default.
• W1490802923 creator A5024645817 @default.
• W1490802923 creator A5037454371 @default.
• W1490802923 creator A5051722584 @default.
• W1490802923 date "2013-11-01" @default.
• W1490802923 modified "2023-09-24" @default.
• W1490802923 title "Blood coagulation induced by Iranian saw-scaled viper (echis carinatus) venom: identification, purification and characterization of a prothrombin activator." @default.
• W1490802923 cites W1532085934 @default.
• W1490802923 cites W1627718954 @default.
• W1490802923 cites W1705854607 @default.
• W1490802923 cites W1749592677 @default.
• W1490802923 cites W1775749144 @default.
• W1490802923 cites W1964564448 @default.
• W1490802923 cites W1966404014 @default.
• W1490802923 cites W1990146359 @default.
• W1490802923 cites W1996242074 @default.
• W1490802923 cites W1998667304 @default.
• W1490802923 cites W2004941257 @default.
• W1490802923 cites W2007037814 @default.
• W1490802923 cites W2020152374 @default.
• W1490802923 cites W2034343739 @default.
• W1490802923 cites W2040939171 @default.
• W1490802923 cites W2044916813 @default.
• W1490802923 cites W2047693344 @default.
• W1490802923 cites W2059991147 @default.
• W1490802923 cites W2065894282 @default.
• W1490802923 cites W2072496595 @default.
• W1490802923 cites W2083519420 @default.
• W1490802923 cites W2100837269 @default.
• W1490802923 cites W2147000186 @default.
• W1490802923 cites W2148187441 @default.
• W1490802923 cites W2156479756 @default.
• W1490802923 cites W2163262951 @default.
• W1490802923 cites W2411910445 @default.
• W1490802923 cites W2417018120 @default.
• W1490802923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3909625" @default.
• W1490802923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24494066" @default.
• W1490802923 hasPublicationYear "2013" @default.
• W1490802923 type Work @default.
• W1490802923 sameAs 1490802923 @default.
• W1490802923 citedByCount "4" @default.
• W1490802923 countsByYear W14908029232014 @default.
• W1490802923 countsByYear W14908029232021 @default.
• W1490802923 countsByYear W14908029232022 @default.
• W1490802923 crossrefType "journal-article" @default.
• W1490802923 hasAuthorship W1490802923A5024645817 @default.
• W1490802923 hasAuthorship W1490802923A5037454371 @default.
• W1490802923 hasAuthorship W1490802923A5051722584 @default.
• W1490802923 hasConcept C112516734 @default.
• W1490802923 hasConcept C126322002 @default.
• W1490802923 hasConcept C146543888 @default.
• W1490802923 hasConcept C163994747 @default.
• W1490802923 hasConcept C181199279 @default.
• W1490802923 hasConcept C185592680 @default.
• W1490802923 hasConcept C193363816 @default.
• W1490802923 hasConcept C203014093 @default.
• W1490802923 hasConcept C2776725428 @default.
• W1490802923 hasConcept C2777292125 @default.
• W1490802923 hasConcept C2778382381 @default.
• W1490802923 hasConcept C2779448229 @default.
• W1490802923 hasConcept C2780434524 @default.
• W1490802923 hasConcept C2910624479 @default.
• W1490802923 hasConcept C43617362 @default.
• W1490802923 hasConcept C55493867 @default.
• W1490802923 hasConcept C71924100 @default.
• W1490802923 hasConcept C89560881 @default.
• W1490802923 hasConceptScore W1490802923C112516734 @default.
• W1490802923 hasConceptScore W1490802923C126322002 @default.
• W1490802923 hasConceptScore W1490802923C146543888 @default.
• W1490802923 hasConceptScore W1490802923C163994747 @default.
• W1490802923 hasConceptScore W1490802923C181199279 @default.
• W1490802923 hasConceptScore W1490802923C185592680 @default.
• W1490802923 hasConceptScore W1490802923C193363816 @default.
• W1490802923 hasConceptScore W1490802923C203014093 @default.
• W1490802923 hasConceptScore W1490802923C2776725428 @default.
• W1490802923 hasConceptScore W1490802923C2777292125 @default.
• W1490802923 hasConceptScore W1490802923C2778382381 @default.
• W1490802923 hasConceptScore W1490802923C2779448229 @default.
• W1490802923 hasConceptScore W1490802923C2780434524 @default.
• W1490802923 hasConceptScore W1490802923C2910624479 @default.
• W1490802923 hasConceptScore W1490802923C43617362 @default.
• W1490802923 hasConceptScore W1490802923C55493867 @default.
• W1490802923 hasConceptScore W1490802923C71924100 @default.
• W1490802923 hasConceptScore W1490802923C89560881 @default.
• W1490802923 hasLocation W14908029231 @default.
• W1490802923 hasOpenAccess W1490802923 @default.
• W1490802923 hasPrimaryLocation W14908029231 @default.
• W1490802923 hasRelatedWork W1705854607 @default.
• W1490802923 hasRelatedWork W1785075666 @default.
• W1490802923 hasRelatedWork W1968516094 @default.
• W1490802923 hasRelatedWork W1985589221 @default.
• W1490802923 hasRelatedWork W1987834154 @default.
• W1490802923 hasRelatedWork W1989184114 @default.
• W1490802923 hasRelatedWork W1990259770 @default.
• W1490802923 hasRelatedWork W2026364454 @default.
• W1490802923 hasRelatedWork W2027566432 @default.
• W1490802923 hasRelatedWork W2065894282 @default.
• W1490802923 hasRelatedWork W2074611274 @default.
• W1490802923 hasRelatedWork W2121253457 @default.

• next