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- W149080587 abstract "Epidemiological studies have suggested that consumption of cruciferous vegetables may significantly decrease the risk of various cancers in humans. The anticarcinogenic activity of crucifers may result from the presence of active compounds in the vegetables. Ascorbigen is one of the indole derivatives formed from cruciferous vegetables. In this study, the effect of ascorbigen on the formation of 7,12-dimethyl[a]benzanthracene (DMBA)-induced mammary tumor was studied in female Sprague-Dawley rats. Rats were divided into four groups which received: (1) a single intubation of 15 mg DMBA without ascorbigen; (2) 15 mg DMBA and two daily intubations of 16 mg ascorbigen; (3) 15 mg DMBA and two intubations of 32.5 mg ascorbigen day-1; (4) 15 mg DMBA and two intubations of 65 mg day-1of ascorbigen. The first tumor appeared in rats treated only with DMBA was found 30 days later; while in all ascorbigen-treated groups it appeared after 40 days. After 90 days, 63% of rats receiving only DMBA showed mammary tumors. Rats receiving ascorbigen at dose levels of 32.5 mg day-1and 65 mg day-1had 33% and 39% incidence of mammary tumors, respectively, while rats receiving 16 mg day-1of ascorbigen did not show decreased tumor incidence. The results of this study suggests that ascorbigen may be a promising chemopreventive agent in DMBA-induced mammary carcinogenesis in rats." @default.
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- W149080587 date "2000-01-01" @default.
- W149080587 modified "2023-10-18" @default.
- W149080587 title "Effect of Ascorbigen on 7,12-Dimethylbenzanthracene-induced Mammary Tumor in Female Sprague-Dawley Rats" @default.
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- W149080587 doi "https://doi.org/10.1533/9781845698188.7.366" @default.
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