FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1490807989> ?p ?o ?g. }

• W1490807989 endingPage "23" @default.
• W1490807989 startingPage "16" @default.
• W1490807989 abstract "Cytoadherence and rosetting contribute to the development of severe Plasmodium falciparum malaria. In Brazil, severe falciparum malaria is mostly associated with renal or pulmonary complications and very rarely with cerebral malaria. The most N-terminal DBL1α domain of PfEMP1, a protein encoded by the var multi-gene family mediates rosetting. We analyzed parasites of Brazilian patients with severe malaria to determine whether there were particular DBL1α var sequences predominantly expressed in such patients. DBL1α var sequences were obtained from parasites of Brazilian patients with severe and mild malaria and were analyzed by standard bioinformatic programs. Three hundred twenty var DBL1α sequences obtained from 80 Brazilian patients with mild malaria were spotted in high-density filters and hybridized to probes representing predominantly expressed sequences in parasites from patients with severe malaria. A DBL1α domain was expressed in bacteria and used to demonstrate its binding capacity to erythrocytes by immunofluorescence. Forty-three different and unreported DBL1α amino acid sequences were obtained. Sequences predominantly expressed in patients with severe malaria could be subgrouped due to deletions of 1–2-cysteine residues. These sequences were commonly found in the var gene repertoire of parasites from patients with mild malaria, yet they were rarely expressed in these patients. A recombinant protein representing the most abundantly expressed sequence detected in one patient with severe malaria bound directly to uninfected erythrocytes. This is the first report showing an association of severe noncerebral malaria from Brazil with particular DBL1α sequences." @default.
• W1490807989 created "2016-06-24" @default.
• W1490807989 creator A5062896436 @default.
• W1490807989 creator A5091647883 @default.
• W1490807989 date "2002-01-01" @default.
• W1490807989 modified "2023-10-16" @default.
• W1490807989 title "Association of Severe Noncerebral Plasmodium falciparum Malaria in Brazil With Expressed PfEMP1 DBL1α Sequences Lacking Cysteine Residues" @default.
• W1490807989 cites W1624420511 @default.
• W1490807989 cites W1679367724 @default.
• W1490807989 cites W169321723 @default.
• W1490807989 cites W191400563 @default.
• W1490807989 cites W1969503178 @default.
• W1490807989 cites W1972358210 @default.
• W1490807989 cites W1985794196 @default.
• W1490807989 cites W2003472864 @default.
• W1490807989 cites W2003541724 @default.
• W1490807989 cites W2020637870 @default.
• W1490807989 cites W2020928512 @default.
• W1490807989 cites W2034254870 @default.
• W1490807989 cites W2049700891 @default.
• W1490807989 cites W2082928585 @default.
• W1490807989 cites W2097382368 @default.
• W1490807989 cites W2112373545 @default.
• W1490807989 cites W2114272562 @default.
• W1490807989 cites W2120596391 @default.
• W1490807989 cites W2132140005 @default.
• W1490807989 cites W2134334225 @default.
• W1490807989 cites W2144481965 @default.
• W1490807989 cites W2158714788 @default.
• W1490807989 cites W2164997158 @default.
• W1490807989 cites W2171784590 @default.
• W1490807989 cites W2336622083 @default.
• W1490807989 cites W2403104789 @default.
• W1490807989 cites W2403302911 @default.
• W1490807989 cites W2404958106 @default.
• W1490807989 cites W2412914271 @default.
• W1490807989 cites W4231646317 @default.
• W1490807989 cites W4243160198 @default.
• W1490807989 doi "https://doi.org/10.1007/bf03401999" @default.
• W1490807989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2039937" @default.
• W1490807989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11984002" @default.
• W1490807989 hasPublicationYear "2002" @default.
• W1490807989 type Work @default.
• W1490807989 sameAs 1490807989 @default.
• W1490807989 citedByCount "97" @default.
• W1490807989 countsByYear W14908079892012 @default.
• W1490807989 countsByYear W14908079892013 @default.
• W1490807989 countsByYear W14908079892014 @default.
• W1490807989 countsByYear W14908079892015 @default.
• W1490807989 countsByYear W14908079892016 @default.
• W1490807989 countsByYear W14908079892017 @default.
• W1490807989 countsByYear W14908079892018 @default.
• W1490807989 countsByYear W14908079892019 @default.
• W1490807989 countsByYear W14908079892020 @default.
• W1490807989 countsByYear W14908079892021 @default.
• W1490807989 countsByYear W14908079892022 @default.
• W1490807989 countsByYear W14908079892023 @default.
• W1490807989 crossrefType "journal-article" @default.
• W1490807989 hasAuthorship W1490807989A5062896436 @default.
• W1490807989 hasAuthorship W1490807989A5091647883 @default.
• W1490807989 hasBestOaLocation W14908079891 @default.
• W1490807989 hasConcept C104317684 @default.
• W1490807989 hasConcept C159047783 @default.
• W1490807989 hasConcept C159654299 @default.
• W1490807989 hasConcept C203014093 @default.
• W1490807989 hasConcept C2778048844 @default.
• W1490807989 hasConcept C2778236600 @default.
• W1490807989 hasConcept C2778371730 @default.
• W1490807989 hasConcept C2908793570 @default.
• W1490807989 hasConcept C40767141 @default.
• W1490807989 hasConcept C54355233 @default.
• W1490807989 hasConcept C86803240 @default.
• W1490807989 hasConceptScore W1490807989C104317684 @default.
• W1490807989 hasConceptScore W1490807989C159047783 @default.
• W1490807989 hasConceptScore W1490807989C159654299 @default.
• W1490807989 hasConceptScore W1490807989C203014093 @default.
• W1490807989 hasConceptScore W1490807989C2778048844 @default.
• W1490807989 hasConceptScore W1490807989C2778236600 @default.
• W1490807989 hasConceptScore W1490807989C2778371730 @default.
• W1490807989 hasConceptScore W1490807989C2908793570 @default.
• W1490807989 hasConceptScore W1490807989C40767141 @default.
• W1490807989 hasConceptScore W1490807989C54355233 @default.
• W1490807989 hasConceptScore W1490807989C86803240 @default.
• W1490807989 hasIssue "1" @default.
• W1490807989 hasLocation W14908079891 @default.
• W1490807989 hasLocation W14908079892 @default.
• W1490807989 hasLocation W14908079893 @default.
• W1490807989 hasOpenAccess W1490807989 @default.
• W1490807989 hasPrimaryLocation W14908079891 @default.
• W1490807989 hasRelatedWork W2039976430 @default.
• W1490807989 hasRelatedWork W2060046542 @default.
• W1490807989 hasRelatedWork W2115261803 @default.
• W1490807989 hasRelatedWork W2130595390 @default.
• W1490807989 hasRelatedWork W2394911427 @default.
• W1490807989 hasRelatedWork W2597473315 @default.
• W1490807989 hasRelatedWork W4247054061 @default.
• W1490807989 hasRelatedWork W4307427571 @default.
• W1490807989 hasRelatedWork W4313325297 @default.

• next