Matches in SemOpenAlex for { <https://semopenalex.org/work/W1491013990> ?p ?o ?g. }
- W1491013990 endingPage "1521" @default.
- W1491013990 startingPage "1514" @default.
- W1491013990 abstract "Abstract Highly active and recoverable nanobioreactors prepared by immobilizing rat liver microsomes on magnetic nanoparticles (LMMNPs) were utilized in metabolic study of Angelica dahurica extracts. Five metabolites were detected in the incubation solution of the extracts and LMMNPs, which were identified by means of HPLC‐MS as trans ‐imperatorin hydroxylate (M1), cis ‐imperatorin hydroxylate (M2), imperatorin epoxide (M3), trans ‐isoimperatorin hydroxylate (M1′) and cis ‐isoimperatorin hydroxylate (speculated M2′). Compared with the metabolisms of imperatorin and isoimperatorin, it was found that the five metabolites were all transformed from these two major compounds present in the plant. Since no study on isoimperatorin metabolism by liver microsomal enzyme system has been reported so far, its metabolites (M1′ and M3′) were isolated by preparative HPLC for structure elucidation by 1 H‐NMR and MS 2 analysis. M3′ was identified as isoimperatorin epoxide, which is a new compound as far as its chemical structure is concerned. However, interestingly, M3′ was not detected in the metabolism of the whole plant extract. In addition, a study with known chemical inhibitors on individual isozymes of the microsomal enzyme family revealed that CYP1A2 is involved in metabolisms of both isoimperatorin and imperatorin, and CYP3A4 only in that of isoimperatorin. Copyright © 2015 John Wiley & Sons, Ltd." @default.
- W1491013990 created "2016-06-24" @default.
- W1491013990 creator A5002748315 @default.
- W1491013990 creator A5003704044 @default.
- W1491013990 creator A5026101786 @default.
- W1491013990 creator A5082580072 @default.
- W1491013990 creator A5084794862 @default.
- W1491013990 creator A5089583113 @default.
- W1491013990 date "2015-03-08" @default.
- W1491013990 modified "2023-10-16" @default.
- W1491013990 title "Metabolic study of<i>Angelica dahurica</i>extracts using a reusable liver microsomal nanobioreactor by liquid chromatography-mass spectrometry" @default.
- W1491013990 cites W1848936363 @default.
- W1491013990 cites W1970477011 @default.
- W1491013990 cites W1976735644 @default.
- W1491013990 cites W1978914226 @default.
- W1491013990 cites W1982348433 @default.
- W1491013990 cites W1984396499 @default.
- W1491013990 cites W1984702842 @default.
- W1491013990 cites W1985448351 @default.
- W1491013990 cites W1990907460 @default.
- W1491013990 cites W1992735251 @default.
- W1491013990 cites W1997018016 @default.
- W1491013990 cites W2000867337 @default.
- W1491013990 cites W2001826948 @default.
- W1491013990 cites W2013349692 @default.
- W1491013990 cites W2016777859 @default.
- W1491013990 cites W2019392073 @default.
- W1491013990 cites W2035684991 @default.
- W1491013990 cites W2036088000 @default.
- W1491013990 cites W2037732568 @default.
- W1491013990 cites W2050289342 @default.
- W1491013990 cites W2050859052 @default.
- W1491013990 cites W2052546737 @default.
- W1491013990 cites W2053255440 @default.
- W1491013990 cites W2058011126 @default.
- W1491013990 cites W2058226245 @default.
- W1491013990 cites W2061172099 @default.
- W1491013990 cites W2069579524 @default.
- W1491013990 cites W2078023969 @default.
- W1491013990 cites W2099346244 @default.
- W1491013990 cites W2128635872 @default.
- W1491013990 cites W2140372661 @default.
- W1491013990 cites W2161022787 @default.
- W1491013990 cites W2410035920 @default.
- W1491013990 cites W2462665594 @default.
- W1491013990 cites W4293247451 @default.
- W1491013990 doi "https://doi.org/10.1002/bmc.3451" @default.
- W1491013990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4562904" @default.
- W1491013990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25753568" @default.
- W1491013990 hasPublicationYear "2015" @default.
- W1491013990 type Work @default.
- W1491013990 sameAs 1491013990 @default.
- W1491013990 citedByCount "6" @default.
- W1491013990 countsByYear W14910139902017 @default.
- W1491013990 countsByYear W14910139902018 @default.
- W1491013990 countsByYear W14910139902019 @default.
- W1491013990 countsByYear W14910139902020 @default.
- W1491013990 crossrefType "journal-article" @default.
- W1491013990 hasAuthorship W1491013990A5002748315 @default.
- W1491013990 hasAuthorship W1491013990A5003704044 @default.
- W1491013990 hasAuthorship W1491013990A5026101786 @default.
- W1491013990 hasAuthorship W1491013990A5082580072 @default.
- W1491013990 hasAuthorship W1491013990A5084794862 @default.
- W1491013990 hasAuthorship W1491013990A5089583113 @default.
- W1491013990 hasBestOaLocation W14910139902 @default.
- W1491013990 hasConcept C179998833 @default.
- W1491013990 hasConcept C181199279 @default.
- W1491013990 hasConcept C185592680 @default.
- W1491013990 hasConcept C2777307396 @default.
- W1491013990 hasConcept C2778692553 @default.
- W1491013990 hasConcept C2781110370 @default.
- W1491013990 hasConcept C2781391307 @default.
- W1491013990 hasConcept C43617362 @default.
- W1491013990 hasConcept C552990157 @default.
- W1491013990 hasConcept C55493867 @default.
- W1491013990 hasConcept C87644729 @default.
- W1491013990 hasConceptScore W1491013990C179998833 @default.
- W1491013990 hasConceptScore W1491013990C181199279 @default.
- W1491013990 hasConceptScore W1491013990C185592680 @default.
- W1491013990 hasConceptScore W1491013990C2777307396 @default.
- W1491013990 hasConceptScore W1491013990C2778692553 @default.
- W1491013990 hasConceptScore W1491013990C2781110370 @default.
- W1491013990 hasConceptScore W1491013990C2781391307 @default.
- W1491013990 hasConceptScore W1491013990C43617362 @default.
- W1491013990 hasConceptScore W1491013990C552990157 @default.
- W1491013990 hasConceptScore W1491013990C55493867 @default.
- W1491013990 hasConceptScore W1491013990C87644729 @default.
- W1491013990 hasFunder F4320321001 @default.
- W1491013990 hasFunder F4320332161 @default.
- W1491013990 hasIssue "10" @default.
- W1491013990 hasLocation W14910139901 @default.
- W1491013990 hasLocation W14910139902 @default.
- W1491013990 hasLocation W14910139903 @default.
- W1491013990 hasLocation W14910139904 @default.
- W1491013990 hasOpenAccess W1491013990 @default.
- W1491013990 hasPrimaryLocation W14910139901 @default.
- W1491013990 hasRelatedWork W1947628619 @default.
- W1491013990 hasRelatedWork W2039459740 @default.