Matches in SemOpenAlex for { <https://semopenalex.org/work/W149105362> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W149105362 endingPage "39.24" @default.
- W149105362 startingPage "39.24" @default.
- W149105362 abstract "Abstract Following virus infection, cytotoxic T lymphocytes (CTL) divide rapidly to eradicate the pathogen and prevent the establishment of persistence. The magnitude of an anti-viral CTL response is thought to be controlled by the initiation of a cell cycle program within lymphoid tissues. However, it is presently not known whether this division program proceeds during migration or is influenced locally at sites of viral infection. Here we demonstrate that anti-viral CTL remain in cell cycle while transiting to infected tissues. One third of virus-specific CTL within blood were found to be in various stages of cell cycle following infection with lymphocytic choriomeningitis virus (LCMV). Using two-photon microscopy, we revealed that effector CTL divided within the virus-infected central nervous system (CNS) as well as meningeal blood vessels. Within the CNS, MHC I-dependent interactions with antigen presenting cells influenced the division program by pushing effector CTL into cell cycle. These results demonstrate that CTL are poised to divide in transit and that their numbers can be influenced at the site of infection through interactions with local APCs." @default.
- W149105362 created "2016-06-24" @default.
- W149105362 creator A5038598245 @default.
- W149105362 creator A5039102232 @default.
- W149105362 creator A5041772105 @default.
- W149105362 creator A5060166478 @default.
- W149105362 creator A5064959537 @default.
- W149105362 date "2010-04-01" @default.
- W149105362 modified "2023-10-18" @default.
- W149105362 title "Continual cell cycle progression during migration permits rapid CTL division at sites of viral infection (39.24)" @default.
- W149105362 doi "https://doi.org/10.4049/jimmunol.184.supp.39.24" @default.
- W149105362 hasPublicationYear "2010" @default.
- W149105362 type Work @default.
- W149105362 sameAs 149105362 @default.
- W149105362 citedByCount "0" @default.
- W149105362 crossrefType "journal-article" @default.
- W149105362 hasAuthorship W149105362A5038598245 @default.
- W149105362 hasAuthorship W149105362A5039102232 @default.
- W149105362 hasAuthorship W149105362A5041772105 @default.
- W149105362 hasAuthorship W149105362A5060166478 @default.
- W149105362 hasAuthorship W149105362A5064959537 @default.
- W149105362 hasConcept C147969180 @default.
- W149105362 hasConcept C1491633281 @default.
- W149105362 hasConcept C154317977 @default.
- W149105362 hasConcept C159047783 @default.
- W149105362 hasConcept C167672396 @default.
- W149105362 hasConcept C202751555 @default.
- W149105362 hasConcept C203014093 @default.
- W149105362 hasConcept C2522874641 @default.
- W149105362 hasConcept C2780190958 @default.
- W149105362 hasConcept C51785407 @default.
- W149105362 hasConcept C54355233 @default.
- W149105362 hasConcept C85813293 @default.
- W149105362 hasConcept C86803240 @default.
- W149105362 hasConcept C8891405 @default.
- W149105362 hasConcept C95444343 @default.
- W149105362 hasConceptScore W149105362C147969180 @default.
- W149105362 hasConceptScore W149105362C1491633281 @default.
- W149105362 hasConceptScore W149105362C154317977 @default.
- W149105362 hasConceptScore W149105362C159047783 @default.
- W149105362 hasConceptScore W149105362C167672396 @default.
- W149105362 hasConceptScore W149105362C202751555 @default.
- W149105362 hasConceptScore W149105362C203014093 @default.
- W149105362 hasConceptScore W149105362C2522874641 @default.
- W149105362 hasConceptScore W149105362C2780190958 @default.
- W149105362 hasConceptScore W149105362C51785407 @default.
- W149105362 hasConceptScore W149105362C54355233 @default.
- W149105362 hasConceptScore W149105362C85813293 @default.
- W149105362 hasConceptScore W149105362C86803240 @default.
- W149105362 hasConceptScore W149105362C8891405 @default.
- W149105362 hasConceptScore W149105362C95444343 @default.
- W149105362 hasIssue "1_Supplement" @default.
- W149105362 hasLocation W1491053621 @default.
- W149105362 hasOpenAccess W149105362 @default.
- W149105362 hasPrimaryLocation W1491053621 @default.
- W149105362 hasRelatedWork W1512074129 @default.
- W149105362 hasRelatedWork W1528734764 @default.
- W149105362 hasRelatedWork W1677464321 @default.
- W149105362 hasRelatedWork W1967398906 @default.
- W149105362 hasRelatedWork W2015747966 @default.
- W149105362 hasRelatedWork W2052483994 @default.
- W149105362 hasRelatedWork W2137835553 @default.
- W149105362 hasRelatedWork W2162330027 @default.
- W149105362 hasRelatedWork W314117022 @default.
- W149105362 hasRelatedWork W4240219718 @default.
- W149105362 hasVolume "184" @default.
- W149105362 isParatext "false" @default.
- W149105362 isRetracted "false" @default.
- W149105362 magId "149105362" @default.
- W149105362 workType "article" @default.