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• W1491115957 endingPage "11254" @default.
• W1491115957 startingPage "11244" @default.
• W1491115957 abstract "NMDA receptors (NMDARs) play a crucial role in neuronal development, synaptic plasticity, and excitotoxicity; therefore, regulation of NMDAR function is important in both physiological and pathological conditions. Previous studies indicate that the NMDAR-mediated synaptic current decay rate increases during development because of a switch in receptor subunit composition, contributing to developmental changes in plasticity. To test whether NMDAR desensitization also changes during development, we recorded whole-cell NMDA-evoked currents in cultured rat hippocampal neurons. We found that glycine-independent desensitization of NMDARs decreases during development. This decrease was not dependent on a switch in subunit composition or differential receptor sensitivity to agonist-, Ca2+-, or Zn2+-induced increase in desensitization. Instead, several lines of evidence indicated that the developmental decrease in desensitization was tightly correlated with synaptic localization of the receptor, suggesting that association of NMDARs with proteins selectively expressed at synapses in mature neurons might account for developmental alterations in desensitization. Accordingly, we tested the role of interactions between PSD-95 (postsynaptic density-95) and NMDARs in regulating receptor desensitization. Overexpression of PSD-95 reduced NMDAR desensitization in immature neurons, whereas agents that interfere with synaptic targeting of PSD-95, or induce movement of NMDARs away from synapses and uncouple the receptor from PSD-95, increased NMDAR desensitization in mature neurons. We conclude that synaptic localization and association with PSD-95 increases stability of hippocampal neuronal NMDAR responses to sustained agonist exposure. Our results elucidate an additional mechanism for differentially regulating NMDAR function in neurons of different developmental stages or the response of subpopulations of NMDARs in a single neuron." @default.
• W1491115957 created "2016-06-24" @default.
• W1491115957 creator A5020418567 @default.
• W1491115957 creator A5027487483 @default.
• W1491115957 creator A5034995105 @default.
• W1491115957 creator A5046794989 @default.
• W1491115957 date "2003-12-03" @default.
• W1491115957 modified "2023-09-26" @default.
• W1491115957 title "Developmental Decrease in NMDA Receptor Desensitization Associated with Shift to Synapse and Interaction with Postsynaptic Density-95" @default.
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• W1491115957 doi "https://doi.org/10.1523/jneurosci.23-35-11244.2003" @default.
• W1491115957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6741033" @default.
• W1491115957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14657184" @default.
• W1491115957 hasPublicationYear "2003" @default.
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