FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1491667701> ?p ?o ?g. }

• W1491667701 abstract "The specification of Primordial Germ Cells (PGCs) in early mammalian development is a fundamental process of development, critical for, maintaining the germ line. There are two methods by which PGCs are specified in the animal kingdom. Firstly, through the predetermined method involving maternally inherited germplasm, and secondly through the induction of pluripotent precursors in a process termed epigenesis. Embryoid Bodies (EBs) can be used to recapitulate early developmental processes of mammalian development, allowing the dissection and better understanding of critical processes. This project will aim to try and better understand the role of the homeobox transcription factor Nanog in specifying PGCs through the process of epigenesis. Mouse Nanog over-expression in EBs has been shown to increase PGC specification, assayed through RT-PCR analysis. The functional activity of ancestral Nanog is hypothesised to be conserved through the major trunk of evolution in organisms that specify PGCs through the induced method of epigenesis. To test this hypothesis, ancient Nanog orthologs were isolated from different positions of the Deuterostome superfamily and over-expressed in EBs. Their effects on enhancing PGC specification were then quantified through quantitative RT-PCR and western blot analysis. The results from this project show that the over-expression of ancient Nanog orthologs in mES cells can enhance the process of PGC specification, by increasing the PGC associated markers Dazl and Vasa. This suggests a possible conservation of functional Nanog activity in organisms that specify PGCs through epigenesis, and also that pluripotency is an ancient trait." @default.
• W1491667701 created "2016-06-24" @default.
• W1491667701 creator A5048290697 @default.
• W1491667701 date "2010-12-10" @default.
• W1491667701 modified "2023-09-26" @default.
• W1491667701 title "Investigating a conserved role for Nanog in primordial germ cell specification" @default.
• W1491667701 cites W1555883074 @default.
• W1491667701 cites W1595011252 @default.
• W1491667701 cites W1602639889 @default.
• W1491667701 cites W1608762409 @default.
• W1491667701 cites W1964887997 @default.
• W1491667701 cites W1965428318 @default.
• W1491667701 cites W1966758700 @default.
• W1491667701 cites W1967380741 @default.
• W1491667701 cites W1976435237 @default.
• W1491667701 cites W1977135603 @default.
• W1491667701 cites W1987983547 @default.
• W1491667701 cites W1992160731 @default.
• W1491667701 cites W1992949513 @default.
• W1491667701 cites W1994758141 @default.
• W1491667701 cites W2003932465 @default.
• W1491667701 cites W2005437050 @default.
• W1491667701 cites W2007003847 @default.
• W1491667701 cites W200794081 @default.
• W1491667701 cites W2011373586 @default.
• W1491667701 cites W2011388270 @default.
• W1491667701 cites W2014542279 @default.
• W1491667701 cites W2016971867 @default.
• W1491667701 cites W2017298826 @default.
• W1491667701 cites W2030441910 @default.
• W1491667701 cites W2031416354 @default.
• W1491667701 cites W2034421167 @default.
• W1491667701 cites W2036174638 @default.
• W1491667701 cites W2038752568 @default.
• W1491667701 cites W2045619208 @default.
• W1491667701 cites W2045677887 @default.
• W1491667701 cites W2045899482 @default.
• W1491667701 cites W2046217837 @default.
• W1491667701 cites W2050518767 @default.
• W1491667701 cites W2053911973 @default.
• W1491667701 cites W2062779167 @default.
• W1491667701 cites W2078337444 @default.
• W1491667701 cites W2086618187 @default.
• W1491667701 cites W2086943348 @default.
• W1491667701 cites W2097206029 @default.
• W1491667701 cites W2118657817 @default.
• W1491667701 cites W2123829995 @default.
• W1491667701 cites W2125987139 @default.
• W1491667701 cites W2126851387 @default.
• W1491667701 cites W2128323764 @default.
• W1491667701 cites W2129832160 @default.
• W1491667701 cites W2138292740 @default.
• W1491667701 cites W2138417516 @default.
• W1491667701 cites W2138977668 @default.
• W1491667701 cites W2143023822 @default.
• W1491667701 cites W2144634347 @default.
• W1491667701 cites W2145296283 @default.
• W1491667701 cites W2147231609 @default.
• W1491667701 cites W2149608498 @default.
• W1491667701 cites W2150163104 @default.
• W1491667701 cites W2151870437 @default.
• W1491667701 cites W3140039958 @default.
• W1491667701 hasPublicationYear "2010" @default.
• W1491667701 type Work @default.
• W1491667701 sameAs 1491667701 @default.
• W1491667701 citedByCount "0" @default.
• W1491667701 crossrefType "dissertation" @default.
• W1491667701 hasAuthorship W1491667701A5048290697 @default.
• W1491667701 hasConcept C104317684 @default.
• W1491667701 hasConcept C107459253 @default.
• W1491667701 hasConcept C121587040 @default.
• W1491667701 hasConcept C145103041 @default.
• W1491667701 hasConcept C207701140 @default.
• W1491667701 hasConcept C54355233 @default.
• W1491667701 hasConcept C86339819 @default.
• W1491667701 hasConcept C86803240 @default.
• W1491667701 hasConcept C95444343 @default.
• W1491667701 hasConceptScore W1491667701C104317684 @default.
• W1491667701 hasConceptScore W1491667701C107459253 @default.
• W1491667701 hasConceptScore W1491667701C121587040 @default.
• W1491667701 hasConceptScore W1491667701C145103041 @default.
• W1491667701 hasConceptScore W1491667701C207701140 @default.
• W1491667701 hasConceptScore W1491667701C54355233 @default.
• W1491667701 hasConceptScore W1491667701C86339819 @default.
• W1491667701 hasConceptScore W1491667701C86803240 @default.
• W1491667701 hasConceptScore W1491667701C95444343 @default.
• W1491667701 hasLocation W14916677011 @default.
• W1491667701 hasOpenAccess W1491667701 @default.
• W1491667701 hasPrimaryLocation W14916677011 @default.
• W1491667701 hasRelatedWork W1551960421 @default.
• W1491667701 hasRelatedWork W1989396399 @default.
• W1491667701 hasRelatedWork W2091385966 @default.
• W1491667701 hasRelatedWork W2103483161 @default.
• W1491667701 hasRelatedWork W2123679196 @default.
• W1491667701 hasRelatedWork W2152363904 @default.
• W1491667701 hasRelatedWork W2185095784 @default.
• W1491667701 hasRelatedWork W2292321876 @default.
• W1491667701 hasRelatedWork W2318101320 @default.
• W1491667701 hasRelatedWork W2765511682 @default.
• W1491667701 hasRelatedWork W2895347924 @default.

• next