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• W1491975479 abstract "Lesions of articular cartilage do not heal spontaneously. One treatment strategy would be to make cartilage in the laboratory by directed chondrogenic differentiation of mesenchymal stem cells (MSCs). To promote our understanding of the molecular control of chondrogenesis, we have compared the changes in microRNAs (miRNAs) during in vitro chondrogenesis of MSCs with those observed in uncultured and dedifferentiated articular chondrocytes (ACs). Several miRNAs showed a reciprocal relationship during the differentiation of MSCs and dedifferentiation of ACs. miR-140-5p and miR-140-3p changed the most during in vitro chondrogenesis, they were the miRNAs most highly expressed in tissue-engineered chondrocytes, and they were also among the miRNAs most highly expressed in uncultured ACs. There was a 57% overlap for the 100 most highly expressed miRNAs in differentiated MSCs and uncultured ACs, but for other miRNAs, the expression pattern was quite different. We transiently and stably inhibited and overexpressed miR-140-5p and miR-140-3p in differentiating MSCs and dedifferentiating ACs, respectively, to describe global effects and identify and validate new targets. Surprisingly, SOX9 and aggrecan proteins were found to be downregulated in anti-miR-140 transduced differentiating MSCs despite unchanged mRNA levels. This suggests that miR-140 stimulates in vitro chondrogenesis by the upregulation of these molecules at the protein level. RALA, a small GTPase, was identified as a miR-140 target and knockdown experiments showed that RALA regulated SOX9 at the protein level. These observations shed new light on the effect of miR-140 for chondrogenesis in vitro and in vivo." @default.
• W1491975479 created "2016-06-24" @default.
• W1491975479 creator A5000072818 @default.
• W1491975479 creator A5026377327 @default.
• W1491975479 creator A5047424172 @default.
• W1491975479 creator A5061926947 @default.
• W1491975479 date "2014-02-01" @default.
• W1491975479 modified "2023-10-14" @default.
• W1491975479 title "microRNA-140 Targets<i>RALA</i>and Regulates Chondrogenic Differentiation of Human Mesenchymal Stem Cells by Translational Enhancement of<i>SOX9</i>and<i>ACAN</i>" @default.
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• W1491975479 doi "https://doi.org/10.1089/scd.2013.0209" @default.
• W1491975479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24063364" @default.
• W1491975479 hasPublicationYear "2014" @default.
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