Matches in SemOpenAlex for { <https://semopenalex.org/work/W1492090615> ?p ?o ?g. }
- W1492090615 abstract "Abstract Synthetic receptors that are solely or at least partly constructed from peptide segments can be regarded as conceptual links between supramolecular chemistry and biochemistry. Many of these receptors therefore share properties characteristic of both these fields. They can be easily modified by using rational design or combinatorial methods, for example. In addition, binding properties are sensitively dependent on receptor conformation, which is in turn controlled by the sequence of the (amino acid) subunits. In this chapter, successful work in the area of synthetic peptide‐derived receptors is presented to illustrate general design principles and the properties that can be achieved. To this end, the receptors are divided into four types: cyclic peptides and cyclic pseudopeptides, conformationally constrained cyclic peptides containing rigid nonnatural subunits, linear peptides with natural and/or nonnatural subunits, and conjugates of abiotic receptors and peptide‐based subunits. The examples demonstrate that not only are peptide‐derived receptors excellent mimics for natural ligands but in some cases they also possess outstanding binding properties when compared to the other types of synthetic receptors studied in supramolecular chemistry." @default.
- W1492090615 created "2016-06-24" @default.
- W1492090615 creator A5086109930 @default.
- W1492090615 date "2012-01-27" @default.
- W1492090615 modified "2023-10-13" @default.
- W1492090615 title "Synthetic Peptide‐Based Receptors" @default.
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- W1492090615 doi "https://doi.org/10.1002/9780470661345.smc064" @default.
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