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- W1492183835 abstract "Summary Some of the interactions of the herpesviruses and their host cells at the molecular level are reviewed. In general, productive infection of cells with most members of the herpes group is qualitatively the same; there is an inhibition of cell-specific macromolecules and a concomitant synthesis of virus-specific components. Cellular DNA synthesis is gradually inhibited in cells infected in logarithmic phase and by 7 to 8 hr postinfection rabbit kidney cells infected with pseudorabies virus no longer synthesize cell-specific DNA. This inhibitory process requires protein synthesis. Several possible mechanisms for this virus-induced inhibition of cellular DNA synthesis are discussed. Infection of cells with the herpesviruses leads to a decrease in the rate of RNA synthesis. There is a rapid inhibition of the synthesis and processing of cellular ribosomal RNA. Although the synthesis of functional cell-specific messenger RNA is completely inhibited, even at relatively early stages of the infectious process, a new species of polyadenylated cell-specific RNA accumulates in the cytoplasm of infected cells. The decrease in the rate of synthesis of cellular RNA as well as the inhibition of the synthesis of cellular messenger RNA is mediated by a virus-induced protein. The type of proteins (cellular or viral) synthesized by herpesvirus-infected cells can be identified by various criteria. There is in the infected cells a gradual inhibition of cell-specific protein synthesis and a concomitant increase in the rate of synthesis of virus-specific proteins. The inhibition of cell-specific protein synthesis is a function coded by the “immediate-early” viral messenger RNA. The implications of these results are discussed in relation to the oncogenic potential of the herpesviruses." @default.
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- W1492183835 date "1973-06-01" @default.
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- W1492183835 title "A brief review of the biochemistry of herpesvirus-host cell interaction." @default.
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