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- W1492184490 abstract "Reports of tetracycline accumulation in human and animal tumors have led a number of investigators to postulate that this drug, if radio-labeled, might have potential as a therapeutic or diagnostic agent. This paper describes attempts to investigate this potential for tritiated tetracycling. The therapeutic studies demonstrated that while a significant reduction in the growth rates of transplanted tumors could be obtained by the administration of heavy doses of TTC relative to uninjected controls, similar reductions were observed in the growth rates of tumors in animals receiving unlabeled TC. In the localization studies in rodents, the concentrations of TTC in normal tissues and tumors were compared and were correlated with the corresponding concentrations of /sup 14/C-thymidine, a measure of proliferative activity." @default.
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- W1492184490 date "1976-10-26" @default.
- W1492184490 modified "2023-09-27" @default.
- W1492184490 title "Potential for tumor therapy with tritiated tetracycline. Summary evaluation. [Animal tests]" @default.
- W1492184490 doi "https://doi.org/10.2172/7124561" @default.
- W1492184490 hasPublicationYear "1976" @default.
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