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- W1492241462 endingPage "210" @default.
- W1492241462 startingPage "186" @default.
- W1492241462 abstract "Human herpesvirus 8 (HHV-8, Kaposi’s-sarcoma-associated herpesvirus) was discovered in 1994, accompanied by tremendous interest in the field of human viral oncology and rapid development of research projects on molecular biological and pathogenesis-related aspects of this novel human -herpesvirus. The virus was found, in short order, to be associated with 2 rare B cell lymphomas, primary effusion lymphoma and multicentric Castleman’s disease, in addition to Kaposi’s sarcoma, in which HHV-8 genomic sequences were first identified. This review summarizes our current understanding not only of the likely mechanisms contributing to HHV-8 oncogenic pathogenesis but also of the functions of key -herpesvirus- conserved and HHV-8-specific genes in virus biology. The underlying message is that HHV-8- induced oncogenesis is a complex process that is likely to involve both paracrine-mediated promotion of cell proliferation and survival by viral lytic gene products and classical cellular transformation induced by the activity of latency proteins. Furthermore, the 3 malignancies associated with HHV-8 infection are likely to be the products of different pathogenic mechanisms, including differential involvement of individual HHV-8 latency and lytic genes." @default.
- W1492241462 created "2016-06-24" @default.
- W1492241462 creator A5030193965 @default.
- W1492241462 creator A5069986166 @default.
- W1492241462 date "2008-01-01" @default.
- W1492241462 modified "2023-09-26" @default.
- W1492241462 title "Molecular Biology of Human Herpesvirus 8 Neoplasia" @default.
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