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- W1492270159 abstract "2305 Objectives Noninvasive reporter imaging gene expression offers opportunities to understand tumor progression, metastasis, and therapy. We investigated the feasibility of dual reporter gene (human sodium iodide symporter and luciferase, hNIS-Luc) to image the therapeutic effect by vascular endothelial growth factor receptor (VEGFR2)-blocking antibody, TTAC-0001. Methods hNIS-Luc vectors were transfected into MDA-MB231 cells. The MDA-MB231 cells were injected subcutaneously in the right flank of Balb/c nude mice. When tumor volume reached approximately 250-300 mm3, the mice were randomized two groups and injected to the tail vein with PBS or TTAC-0001 (100 μg) every 3 days for 16 days. Gamma imaging and bioluminescence imaging were performed for monitoring the tumor therapy. To verify the therapeutic effect of TTAC-0001, CD31 stain was performed. Results TTAC-0001 reduced markedly the tumor growth rate compare with the control group. In the TTAC-0001 group, hNIS protein expression of tumors was significantly lower than that of tumors in the control group. In vivo tumor imaging by hNIS-Luc gene was correlated to tumor growth. CD31 staining for angiogenesis showed that vessel formation was significantly decreased in TTAC-0001 treated tumors. Conclusions The dual reporter gene hNIS-Luc could be very useful to monitor and image the change of tumor growth by TTAC-0001 therapy." @default.
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- W1492270159 date "2009-05-01" @default.
- W1492270159 modified "2023-09-27" @default.
- W1492270159 title "Monitoring usability of hNIS-luciferase dual gene in tumor therapy using VEGFR2-blocking antibody" @default.
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