FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1492304082> ?p ?o ?g. }

• W1492304082 endingPage "1948" @default.
• W1492304082 startingPage "1940" @default.
• W1492304082 abstract "BACKGROUND: Recombinant immunoblot assay (RIBA) is used to determine the specificity of antibody to hepatitis C virus (anti‐HCV). The RIBA result is recorded as positive, negative, or indeterminate. The interpretation and significance of RIBA‐indeterminate reactions are unclear. We addressed the clinical relevance of these reactions in the context of the natural history of HCV infection in a prospectively followed cohort of anti‐HCV–positive blood donors. STUDY DESIGN AND METHODS: Donor demographics, exposure history, and humoral and cell‐mediated immunity (CMI) were compared in 15 RIBA‐indeterminate subjects, nine chronic HCV carriers, and eight spontaneously recovered subjects. Serum samples were tested for anti‐HCV by a quantitative, liquid luciferase immunoprecipitation system (LIPS). CMI was assessed by interferon‐γ enzyme‐linked immunosorbent spot assay. RESULTS: In the LIPS assay, the sum of antibody responses to six HCV antigens showed significant (p < 0.001) stepwise diminution progressing from chronic carriers to spontaneously recovered to RIBA‐indeterminate subjects. CMI responses in RIBA‐indeterminate subjects were similar to spontaneously recovered subjects and greater than chronic carriers and controls (p < 0.008). A parenteral risk factor was identified in only 13% of RIBA‐indeterminate subjects compared to 89% of chronic carriers and 87% of spontaneously recovered subjects. RIBA‐indeterminate donors were older than the other groups. CONCLUSION: The CMI and LIPS results suggest that persistent RIBA‐indeterminate reactions represent waning anti‐HCV responses in persons who have recovered from a remote HCV infection. In such cases, detectable antibody may ultimately disappear leaving no residual serologic evidence of prior HCV infection, as reported in a minority of long‐term HCV‐recovered subjects." @default.
• W1492304082 created "2016-06-24" @default.
• W1492304082 creator A5002348230 @default.
• W1492304082 creator A5011221249 @default.
• W1492304082 creator A5028100145 @default.
• W1492304082 creator A5041450311 @default.
• W1492304082 creator A5049621807 @default.
• W1492304082 creator A5061367659 @default.
• W1492304082 creator A5086222169 @default.
• W1492304082 creator A5090851948 @default.
• W1492304082 date "2012-02-05" @default.
• W1492304082 modified "2023-10-16" @default.
• W1492304082 title "The clinical relevance of persistent recombinant immunoblot assay-indeterminate reactions: insights into the natural history of hepatitis C virus infection and implications for donor counseling" @default.
• W1492304082 cites W1505139021 @default.
• W1492304082 cites W1511803520 @default.
• W1492304082 cites W1828267096 @default.
• W1492304082 cites W1972208581 @default.
• W1492304082 cites W1991378085 @default.
• W1492304082 cites W1999858864 @default.
• W1492304082 cites W2013740977 @default.
• W1492304082 cites W2014472957 @default.
• W1492304082 cites W2021171572 @default.
• W1492304082 cites W2052402745 @default.
• W1492304082 cites W2066124462 @default.
• W1492304082 cites W2066720352 @default.
• W1492304082 cites W2076260829 @default.
• W1492304082 cites W2107610652 @default.
• W1492304082 cites W2121127500 @default.
• W1492304082 cites W2124352443 @default.
• W1492304082 cites W2129054887 @default.
• W1492304082 cites W2146091571 @default.
• W1492304082 cites W2149987135 @default.
• W1492304082 cites W2153346747 @default.
• W1492304082 cites W2162127770 @default.
• W1492304082 cites W2164285933 @default.
• W1492304082 cites W2333452860 @default.
• W1492304082 doi "https://doi.org/10.1111/j.1537-2995.2011.03524.x" @default.
• W1492304082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3346857" @default.
• W1492304082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22304422" @default.
• W1492304082 hasPublicationYear "2012" @default.
• W1492304082 type Work @default.
• W1492304082 sameAs 1492304082 @default.
• W1492304082 citedByCount "23" @default.
• W1492304082 countsByYear W14923040822012 @default.
• W1492304082 countsByYear W14923040822013 @default.
• W1492304082 countsByYear W14923040822014 @default.
• W1492304082 countsByYear W14923040822015 @default.
• W1492304082 countsByYear W14923040822016 @default.
• W1492304082 countsByYear W14923040822017 @default.
• W1492304082 countsByYear W14923040822018 @default.
• W1492304082 countsByYear W14923040822019 @default.
• W1492304082 countsByYear W14923040822021 @default.
• W1492304082 countsByYear W14923040822023 @default.
• W1492304082 crossrefType "journal-article" @default.
• W1492304082 hasAuthorship W1492304082A5002348230 @default.
• W1492304082 hasAuthorship W1492304082A5011221249 @default.
• W1492304082 hasAuthorship W1492304082A5028100145 @default.
• W1492304082 hasAuthorship W1492304082A5041450311 @default.
• W1492304082 hasAuthorship W1492304082A5049621807 @default.
• W1492304082 hasAuthorship W1492304082A5061367659 @default.
• W1492304082 hasAuthorship W1492304082A5086222169 @default.
• W1492304082 hasAuthorship W1492304082A5090851948 @default.
• W1492304082 hasBestOaLocation W14923040822 @default.
• W1492304082 hasConcept C126322002 @default.
• W1492304082 hasConcept C147483822 @default.
• W1492304082 hasConcept C151730666 @default.
• W1492304082 hasConcept C159047783 @default.
• W1492304082 hasConcept C159654299 @default.
• W1492304082 hasConcept C202444582 @default.
• W1492304082 hasConcept C203014093 @default.
• W1492304082 hasConcept C2522874641 @default.
• W1492304082 hasConcept C2776408679 @default.
• W1492304082 hasConcept C2779343474 @default.
• W1492304082 hasConcept C2780727368 @default.
• W1492304082 hasConcept C33923547 @default.
• W1492304082 hasConcept C45189115 @default.
• W1492304082 hasConcept C63363279 @default.
• W1492304082 hasConcept C71924100 @default.
• W1492304082 hasConcept C86803240 @default.
• W1492304082 hasConcept C94624232 @default.
• W1492304082 hasConceptScore W1492304082C126322002 @default.
• W1492304082 hasConceptScore W1492304082C147483822 @default.
• W1492304082 hasConceptScore W1492304082C151730666 @default.
• W1492304082 hasConceptScore W1492304082C159047783 @default.
• W1492304082 hasConceptScore W1492304082C159654299 @default.
• W1492304082 hasConceptScore W1492304082C202444582 @default.
• W1492304082 hasConceptScore W1492304082C203014093 @default.
• W1492304082 hasConceptScore W1492304082C2522874641 @default.
• W1492304082 hasConceptScore W1492304082C2776408679 @default.
• W1492304082 hasConceptScore W1492304082C2779343474 @default.
• W1492304082 hasConceptScore W1492304082C2780727368 @default.
• W1492304082 hasConceptScore W1492304082C33923547 @default.
• W1492304082 hasConceptScore W1492304082C45189115 @default.
• W1492304082 hasConceptScore W1492304082C63363279 @default.
• W1492304082 hasConceptScore W1492304082C71924100 @default.
• W1492304082 hasConceptScore W1492304082C86803240 @default.
• W1492304082 hasConceptScore W1492304082C94624232 @default.
• W1492304082 hasIssue "9" @default.

• next