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- W1492472464 abstract "Abstract : Camptothecin analogues have been developed that show enhanced pre-clinical activity against breast cancer cells. These analogues have been synthesized with two fundamental modifications that aid in their effectiveness against breast cancer: (1) they have a glycinate ester of the 20(S)-OH group, which aids in both solubility and stabilization of the drug's lactone ring; and (2) they possess a 9-chloro substitution, which allows them to covalently link to DNA. We have studied the activity of these compounds against breast cancer cells in a series of in vitro tests: growth inhibitory activity, clonogenic survival assays, and inhibition of topoisomerase I catalytic activity." @default.
- W1492472464 created "2016-06-24" @default.
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- W1492472464 date "1999-06-01" @default.
- W1492472464 modified "2023-09-27" @default.
- W1492472464 title "DNA Topoisomerase I-Targeted Therapy for Breast Cancer" @default.
- W1492472464 doi "https://doi.org/10.21236/ada371201" @default.
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