Matches in SemOpenAlex for { <https://semopenalex.org/work/W1492542185> ?p ?o ?g. }
- W1492542185 endingPage "154" @default.
- W1492542185 startingPage "144" @default.
- W1492542185 abstract "MyD88 is an adaptor protein involved in the interleukin-1 receptor-induced and Toll-like receptor (TLR)-induced activation of nuclear factor-κB (NF-κB). In this study, we identified two isoforms of MyD88 gene, designated DuMyD88-X1 and DuMyD88-X2, from duck cells. Both variants were determined to have a death domain at the N-terminal and a Toll/IL-1R (TIR) domain at the C-terminal; however, the TIR domain of DuMyD88-X2 was incomplete and was 81 amino acids shorter than DuMyD88-X1. Quantitative real-time reverse transcription PCR revealed broad expression of both MyD88s. During Newcastle disease virus (NDV) challenge experiments, expression of the two genes increased significantly, with DuMyD88-X1 having a larger amplitude and longer duration. Overexpression of DuMyD88-X1 and DuMyD88-X2 induced the activation of NF-κB and IL-6 in vitro, suggesting that DuMyD88-X1 and DuMyD88-X2 may be important in the innate immune response. The results verify the existence of a MyD88-dependent signaling pathway in ducks and contribute to understanding the potential role of MyD88s in the innate immune response." @default.
- W1492542185 created "2016-06-24" @default.
- W1492542185 creator A5025696708 @default.
- W1492542185 creator A5029416150 @default.
- W1492542185 creator A5034769669 @default.
- W1492542185 creator A5065570155 @default.
- W1492542185 creator A5081007687 @default.
- W1492542185 date "2015-10-01" @default.
- W1492542185 modified "2023-10-14" @default.
- W1492542185 title "Two myeloid differentiation factor 88 (MyD88) isoforms identified in ducks" @default.
- W1492542185 cites W1557316591 @default.
- W1492542185 cites W1677119557 @default.
- W1492542185 cites W1967463201 @default.
- W1492542185 cites W1967824654 @default.
- W1492542185 cites W1968440197 @default.
- W1492542185 cites W1969501356 @default.
- W1492542185 cites W1969941746 @default.
- W1492542185 cites W1978737882 @default.
- W1492542185 cites W1979838502 @default.
- W1492542185 cites W1983470819 @default.
- W1492542185 cites W1983959087 @default.
- W1492542185 cites W2001256354 @default.
- W1492542185 cites W2004136719 @default.
- W1492542185 cites W2004465286 @default.
- W1492542185 cites W2010621687 @default.
- W1492542185 cites W2016782127 @default.
- W1492542185 cites W2019712119 @default.
- W1492542185 cites W2026575463 @default.
- W1492542185 cites W2030103839 @default.
- W1492542185 cites W2043268125 @default.
- W1492542185 cites W2044261235 @default.
- W1492542185 cites W2053429123 @default.
- W1492542185 cites W2072578754 @default.
- W1492542185 cites W2074150439 @default.
- W1492542185 cites W2075623297 @default.
- W1492542185 cites W2077072873 @default.
- W1492542185 cites W2078933608 @default.
- W1492542185 cites W2079156871 @default.
- W1492542185 cites W2081421614 @default.
- W1492542185 cites W2085708799 @default.
- W1492542185 cites W2093921410 @default.
- W1492542185 cites W2098485561 @default.
- W1492542185 cites W2107277218 @default.
- W1492542185 cites W2108222684 @default.
- W1492542185 cites W2108578752 @default.
- W1492542185 cites W2109491705 @default.
- W1492542185 cites W2114048032 @default.
- W1492542185 cites W2115185894 @default.
- W1492542185 cites W2121967526 @default.
- W1492542185 cites W2135782580 @default.
- W1492542185 cites W2138802551 @default.
- W1492542185 cites W2170252293 @default.
- W1492542185 doi "https://doi.org/10.1016/j.dci.2015.03.015" @default.
- W1492542185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26004012" @default.
- W1492542185 hasPublicationYear "2015" @default.
- W1492542185 type Work @default.
- W1492542185 sameAs 1492542185 @default.
- W1492542185 citedByCount "12" @default.
- W1492542185 countsByYear W14925421852016 @default.
- W1492542185 countsByYear W14925421852017 @default.
- W1492542185 countsByYear W14925421852018 @default.
- W1492542185 countsByYear W14925421852019 @default.
- W1492542185 countsByYear W14925421852020 @default.
- W1492542185 countsByYear W14925421852022 @default.
- W1492542185 countsByYear W14925421852023 @default.
- W1492542185 crossrefType "journal-article" @default.
- W1492542185 hasAuthorship W1492542185A5025696708 @default.
- W1492542185 hasAuthorship W1492542185A5029416150 @default.
- W1492542185 hasAuthorship W1492542185A5034769669 @default.
- W1492542185 hasAuthorship W1492542185A5065570155 @default.
- W1492542185 hasAuthorship W1492542185A5081007687 @default.
- W1492542185 hasConcept C104317684 @default.
- W1492542185 hasConcept C136449434 @default.
- W1492542185 hasConcept C153911025 @default.
- W1492542185 hasConcept C170493617 @default.
- W1492542185 hasConcept C183786373 @default.
- W1492542185 hasConcept C190283241 @default.
- W1492542185 hasConcept C203014093 @default.
- W1492542185 hasConcept C2776709828 @default.
- W1492542185 hasConcept C2779004061 @default.
- W1492542185 hasConcept C31573885 @default.
- W1492542185 hasConcept C53345823 @default.
- W1492542185 hasConcept C54355233 @default.
- W1492542185 hasConcept C62478195 @default.
- W1492542185 hasConcept C86339819 @default.
- W1492542185 hasConcept C86803240 @default.
- W1492542185 hasConcept C8891405 @default.
- W1492542185 hasConcept C95444343 @default.
- W1492542185 hasConceptScore W1492542185C104317684 @default.
- W1492542185 hasConceptScore W1492542185C136449434 @default.
- W1492542185 hasConceptScore W1492542185C153911025 @default.
- W1492542185 hasConceptScore W1492542185C170493617 @default.
- W1492542185 hasConceptScore W1492542185C183786373 @default.
- W1492542185 hasConceptScore W1492542185C190283241 @default.
- W1492542185 hasConceptScore W1492542185C203014093 @default.
- W1492542185 hasConceptScore W1492542185C2776709828 @default.
- W1492542185 hasConceptScore W1492542185C2779004061 @default.
- W1492542185 hasConceptScore W1492542185C31573885 @default.