FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1492659150> ?p ?o ?g. }

• W1492659150 abstract "Parkinson’s disease (PD) has traditionally been thought of as a dysfunction in the dopamine (DA) signaling system caused primarily by cell death in the substantia nigra pars compacta (SNc). However, strong evidence has been accumulating that the serotonin (5-HT) signaling system is also involved. First, 5-HT influences normal motor function through a dense innervation of the striatum. Second, substantial cell death of serotonergic neurons occurs in PD and in some cases may occur earlier than DA cell death. And, finally, there are indications that interactions between the 5-HT system and the DA system may be responsible for some of the symptoms of PD and some of the side effects of treatment by levodopa. Some of the evidence for these assertions is reviewed below. The 5-HT system is itself very complex. The serotonergic neurons in the raphe nuclei (RN) send ascending projections to a large number of different brain regions including medial prefrontal cortex (mPFC), motor cortex, hypothalamus, hippocampus, amygdala, and the basal ganglia. And, some of these brain regions, substantia nigra, amygdala, mPFC, and hypothalamus send projections back to the RN (Monti, 2010). Thus it is not surprising that 5-HT is linked to so many behaviors including feeding and body-weight regulation, social hierarchies, aggression and suicidality, obsessive compulsive disorder, alcoholism, anxiety, and affective disorders (Feldman et al., 1997). Since the pharmacology and the electrophysiology of both the serotonergic and the dopaminergic systems are only partially understood, it is a daunting task to understand how these two systems affect one another. This is particularly true in the presence of a degenerative disease that involves massive cell death in both systems. In this complicated situation, mathematical models can potentially provide insight into mechanisms and interactions. The purpose of the models is not to summarize what is already known. The purpose is to provide a platform for in silico biological experimentation. Using models one can try out ideas, validate or refute hypotheses, settle disputes in the literature, and sometimes discover new phenomena. Of course, to be useful the models have to be well-grounded in real physiology and the creation of such models is not easy. However, if one 18" @default.
• W1492659150 created "2016-06-24" @default.
• W1492659150 creator A5047159374 @default.
• W1492659150 creator A5070312922 @default.
• W1492659150 creator A5079381603 @default.
• W1492659150 creator A5089610339 @default.
• W1492659150 date "2011-10-12" @default.
• W1492659150 modified "2023-09-25" @default.
• W1492659150 title "Mathematical Models: Interactions Between Serotonin and Dopamine in Parkinson’s Disease" @default.
• W1492659150 cites W1543276710 @default.
• W1492659150 cites W1571821264 @default.
• W1492659150 cites W1662108418 @default.
• W1492659150 cites W1826125636 @default.
• W1492659150 cites W1865166881 @default.
• W1492659150 cites W1896363601 @default.
• W1492659150 cites W1933235205 @default.
• W1492659150 cites W1964978489 @default.
• W1492659150 cites W1965776451 @default.
• W1492659150 cites W1968536838 @default.
• W1492659150 cites W1971675647 @default.
• W1492659150 cites W1972252092 @default.
• W1492659150 cites W1979553190 @default.
• W1492659150 cites W1979767669 @default.
• W1492659150 cites W1980452368 @default.
• W1492659150 cites W1982535961 @default.
• W1492659150 cites W1988107743 @default.
• W1492659150 cites W1991123914 @default.
• W1492659150 cites W1992633971 @default.
• W1492659150 cites W1994410954 @default.
• W1492659150 cites W1994911797 @default.
• W1492659150 cites W1995565667 @default.
• W1492659150 cites W1997521545 @default.
• W1492659150 cites W1998649401 @default.
• W1492659150 cites W1999984492 @default.
• W1492659150 cites W2003943670 @default.
• W1492659150 cites W2004413980 @default.
• W1492659150 cites W2007908680 @default.
• W1492659150 cites W2012298357 @default.
• W1492659150 cites W2013507314 @default.
• W1492659150 cites W2014851193 @default.
• W1492659150 cites W2018996882 @default.
• W1492659150 cites W2020177305 @default.
• W1492659150 cites W2027671925 @default.
• W1492659150 cites W2028842808 @default.
• W1492659150 cites W2033092161 @default.
• W1492659150 cites W2040628755 @default.
• W1492659150 cites W2040798945 @default.
• W1492659150 cites W2043235067 @default.
• W1492659150 cites W2044908785 @default.
• W1492659150 cites W2049665308 @default.
• W1492659150 cites W2053473574 @default.
• W1492659150 cites W2054821578 @default.
• W1492659150 cites W2055626952 @default.
• W1492659150 cites W2055955248 @default.
• W1492659150 cites W2072219714 @default.
• W1492659150 cites W2072447647 @default.
• W1492659150 cites W2072812277 @default.
• W1492659150 cites W2076112136 @default.
• W1492659150 cites W2077500805 @default.
• W1492659150 cites W2077703246 @default.
• W1492659150 cites W2081299043 @default.
• W1492659150 cites W2085861484 @default.
• W1492659150 cites W2090187118 @default.
• W1492659150 cites W2092377028 @default.
• W1492659150 cites W2092858412 @default.
• W1492659150 cites W2095649828 @default.
• W1492659150 cites W2097863680 @default.
• W1492659150 cites W2101113365 @default.
• W1492659150 cites W2107254875 @default.
• W1492659150 cites W2112917428 @default.
• W1492659150 cites W2115222037 @default.
• W1492659150 cites W2115871055 @default.
• W1492659150 cites W2120317655 @default.
• W1492659150 cites W2125418292 @default.
• W1492659150 cites W2132881915 @default.
• W1492659150 cites W2133527428 @default.
• W1492659150 cites W2141311399 @default.
• W1492659150 cites W2145954079 @default.
• W1492659150 cites W2147411610 @default.
• W1492659150 cites W2155712907 @default.
• W1492659150 cites W2162786497 @default.
• W1492659150 cites W2164142966 @default.
• W1492659150 cites W2164398262 @default.
• W1492659150 cites W2272922490 @default.
• W1492659150 cites W2328593025 @default.
• W1492659150 cites W2368752830 @default.
• W1492659150 doi "https://doi.org/10.5772/19897" @default.
• W1492659150 hasPublicationYear "2011" @default.
• W1492659150 type Work @default.
• W1492659150 sameAs 1492659150 @default.
• W1492659150 citedByCount "3" @default.
• W1492659150 countsByYear W14926591502015 @default.
• W1492659150 countsByYear W14926591502017 @default.
• W1492659150 countsByYear W14926591502021 @default.
• W1492659150 crossrefType "book-chapter" @default.
• W1492659150 hasAuthorship W1492659150A5047159374 @default.
• W1492659150 hasAuthorship W1492659150A5070312922 @default.
• W1492659150 hasAuthorship W1492659150A5079381603 @default.
• W1492659150 hasAuthorship W1492659150A5089610339 @default.
• W1492659150 hasBestOaLocation W14926591501 @default.

• next