FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1492672801> ?p ?o ?g. }

• W1492672801 endingPage "84" @default.
• W1492672801 startingPage "77" @default.
• W1492672801 abstract "Abstract graphic Alcohol use is a leading cause of preventable morbidity and mortality worldwide, with much of its negative impact as the result of alcoholic liver disease ( ALD ). ALD is a broad term that encompasses a spectrum of phenotypes ranging from simple steatosis to steatohepatitis, progressive fibrosis, cirrhosis, and hepatocellular carcinoma. The mechanisms underlying the development of these different disease stages are incompletely understood. Standard treatment of ALD , which includes abstinence, nutritional support, and corticosteroids, has not changed in the last 40 years despite continued poor outcomes. Novel therapies are therefore urgently needed. The development of such therapies has been hindered by inadequate resources for research and unsuitable animal models. However, recent developments in translational research have allowed for identification of new potential targets for therapy. These targets include: (i) CXC chemokines, (ii) IL ‐22/ STAT 3, (iii) TNF receptor superfamily, (iv) osteopontin, (v) gut microbiota and lipopolysaccharide ( LPS ), (vi) endocannabinoids, and (vii) inflammasomes. We review the natural history, risk factors, pathogenesis, and current treatments for ALD . We further discuss the findings of recent translational studies and potential therapeutic targets." @default.
• W1492672801 created "2016-06-24" @default.
• W1492672801 creator A5029643477 @default.
• W1492672801 creator A5035086772 @default.
• W1492672801 creator A5040299454 @default.
• W1492672801 date "2013-07-15" @default.
• W1492672801 modified "2023-10-14" @default.
• W1492672801 title "Alcoholic liver disease: Pathogenesis, management, and novel targets for therapy" @default.
• W1492672801 cites W1688714899 @default.
• W1492672801 cites W1889183644 @default.
• W1492672801 cites W1966064283 @default.
• W1492672801 cites W1967964480 @default.
• W1492672801 cites W1968460020 @default.
• W1492672801 cites W1974580919 @default.
• W1492672801 cites W1975805815 @default.
• W1492672801 cites W1976849547 @default.
• W1492672801 cites W1977012152 @default.
• W1492672801 cites W1981368166 @default.
• W1492672801 cites W1982824193 @default.
• W1492672801 cites W1984878174 @default.
• W1492672801 cites W1986039224 @default.
• W1492672801 cites W1987296974 @default.
• W1492672801 cites W1988990189 @default.
• W1492672801 cites W1990492557 @default.
• W1492672801 cites W1991161256 @default.
• W1492672801 cites W1993055449 @default.
• W1492672801 cites W1995501935 @default.
• W1492672801 cites W1995628156 @default.
• W1492672801 cites W1999924323 @default.
• W1492672801 cites W2000194765 @default.
• W1492672801 cites W2000466809 @default.
• W1492672801 cites W2001288327 @default.
• W1492672801 cites W2002221121 @default.
• W1492672801 cites W2003877166 @default.
• W1492672801 cites W2004317356 @default.
• W1492672801 cites W2005551174 @default.
• W1492672801 cites W2006187783 @default.
• W1492672801 cites W2007258272 @default.
• W1492672801 cites W2011574523 @default.
• W1492672801 cites W2018346422 @default.
• W1492672801 cites W2026464825 @default.
• W1492672801 cites W2028538822 @default.
• W1492672801 cites W2029071235 @default.
• W1492672801 cites W2030010285 @default.
• W1492672801 cites W2030954141 @default.
• W1492672801 cites W2032015767 @default.
• W1492672801 cites W2035086157 @default.
• W1492672801 cites W2037038225 @default.
• W1492672801 cites W2038946905 @default.
• W1492672801 cites W2039257980 @default.
• W1492672801 cites W2045322976 @default.
• W1492672801 cites W2045642603 @default.
• W1492672801 cites W2046669555 @default.
• W1492672801 cites W2047438155 @default.
• W1492672801 cites W2049941037 @default.
• W1492672801 cites W2057594695 @default.
• W1492672801 cites W2057607705 @default.
• W1492672801 cites W2057641970 @default.
• W1492672801 cites W2059395784 @default.
• W1492672801 cites W2062564526 @default.
• W1492672801 cites W2063637578 @default.
• W1492672801 cites W2063949300 @default.
• W1492672801 cites W2071618685 @default.
• W1492672801 cites W2073048831 @default.
• W1492672801 cites W2073925856 @default.
• W1492672801 cites W2076078537 @default.
• W1492672801 cites W2076282795 @default.
• W1492672801 cites W2076862430 @default.
• W1492672801 cites W2078033902 @default.
• W1492672801 cites W2079295499 @default.
• W1492672801 cites W2080269795 @default.
• W1492672801 cites W2080656571 @default.
• W1492672801 cites W2086396801 @default.
• W1492672801 cites W2087396305 @default.
• W1492672801 cites W2091647757 @default.
• W1492672801 cites W2092677426 @default.
• W1492672801 cites W2094385682 @default.
• W1492672801 cites W2095935706 @default.
• W1492672801 cites W2098629194 @default.
• W1492672801 cites W2098716682 @default.
• W1492672801 cites W2099360240 @default.
• W1492672801 cites W2102422505 @default.
• W1492672801 cites W2107306217 @default.
• W1492672801 cites W2108925963 @default.
• W1492672801 cites W2109223100 @default.
• W1492672801 cites W2109579153 @default.
• W1492672801 cites W2114769428 @default.
• W1492672801 cites W2118005762 @default.
• W1492672801 cites W2125591748 @default.
• W1492672801 cites W2126503463 @default.
• W1492672801 cites W2133489393 @default.
• W1492672801 cites W2133875539 @default.
• W1492672801 cites W2135155547 @default.
• W1492672801 cites W2135530906 @default.
• W1492672801 cites W2137082205 @default.
• W1492672801 cites W2137128945 @default.
• W1492672801 cites W2137506791 @default.
• W1492672801 cites W2138808174 @default.

• next