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- W1492796529 abstract "Recent studies suggest that megakaryocytes (MKs) may play a significant role in skeletal homeostasis, as evident by the occurrence of osteosclerosis in multiple MK related diseases (Lennert et al., 1975; Thiele et al., 1999; Chagraoui et al., 2006). We previously reported a novel interaction whereby MKs enhanced proliferation of osteoblast lineage/osteoprogenitor cells (OBs) by a mechanism requiring direct cell-cell contact. However, the signal transduction pathways and the downstream effector molecules involved in this process have not been characterized. Here we show that MKs contact with OBs, via beta1 integrin, activate the p38/MAPKAPK2/p90RSK kinase cascade in the bone cells, which causes Mdm2 to neutralizes p53/Rb-mediated check point and allows progression through the G1/S. Interestingly, activation of MAPK (ERK1/2) and AKT, collateral pathways that regulate the cell cycle, remained unchanged with MK stimulation of OBs. The MK-to-OB signaling ultimately results in significant increases in the expression of c-fos and cyclin A, necessary for sustaining the OB proliferation. Overall, our findings show that OBs respond to the presence of MKs, in part, via an integrin-mediated signaling mechanism, activating a novel response axis that de-represses cell cycle activity. Understanding the mechanisms by which MKs enhance OB proliferation will facilitate the development of novel anabolic therapies to treat bone loss associated with osteoporosis and other bone-related diseases." @default.
- W1492796529 created "2016-06-24" @default.
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- W1492796529 date "2014-11-21" @default.
- W1492796529 modified "2023-10-05" @default.
- W1492796529 title "Signaling Pathways Involved in Megakaryocyte-Mediated Proliferation of Osteoblast Lineage Cells" @default.
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- W1492796529 cites W1856360008 @default.
- W1492796529 cites W187681051 @default.
- W1492796529 cites W1905985436 @default.
- W1492796529 cites W1927178045 @default.
- W1492796529 cites W1969726379 @default.
- W1492796529 cites W1971987125 @default.
- W1492796529 cites W1972224144 @default.
- W1492796529 cites W1976303159 @default.
- W1492796529 cites W1978114185 @default.
- W1492796529 cites W1981000558 @default.
- W1492796529 cites W1982622947 @default.
- W1492796529 cites W1984064533 @default.
- W1492796529 cites W1984168185 @default.
- W1492796529 cites W1986512406 @default.
- W1492796529 cites W1990882829 @default.
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- W1492796529 cites W2003923106 @default.
- W1492796529 cites W2003946870 @default.
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- W1492796529 cites W2012034467 @default.
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- W1492796529 cites W2040549178 @default.
- W1492796529 cites W2042095186 @default.
- W1492796529 cites W2048981268 @default.
- W1492796529 cites W2049869441 @default.
- W1492796529 cites W2050745715 @default.
- W1492796529 cites W2052507438 @default.
- W1492796529 cites W2053432671 @default.
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- W1492796529 cites W2064676609 @default.
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- W1492796529 cites W2084147994 @default.
- W1492796529 cites W2088360757 @default.
- W1492796529 cites W2090692711 @default.
- W1492796529 cites W2093228291 @default.
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- W1492796529 cites W2134858249 @default.
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- W1492796529 cites W2169045667 @default.
- W1492796529 cites W2176573977 @default.
- W1492796529 cites W2327321109 @default.
- W1492796529 cites W2409694675 @default.
- W1492796529 cites W2411289820 @default.
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- W1492796529 doi "https://doi.org/10.1002/jcp.24774" @default.
- W1492796529 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4433553" @default.
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