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• W1492802015 abstract "Castration-resistant prostate cancer (CRPC) and its treatment are challenging issues in prostate cancer management. Here, we report that miR-663 is upregulated in CRPC tissues. Overexpression of miR-663 in prostate LNCaP cells promotes cell proliferation and invasion, neuroendocrine differentiation, and reduction in dihydrotestosterone-induced upregulation of prostate-specific antigen expression. Furthermore, results of in situ hybridization show that miR-663 expression is correlated with Gleason score and TNM stage and is an independent prognostic predictor of clinical recurrence. Together, these findings suggest that miR-663 is a potential oncomiR for CRPC and may serve as a tumor biomarker for the early diagnosis of CRPC. J. Cell. Physiol. 229: 834–844, 2014. © 2013 Wiley Periodicals, Inc." @default.
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• W1492802015 date "2014-03-21" @default.
• W1492802015 modified "2023-10-15" @default.
• W1492802015 title "miR-663 Induces Castration-Resistant Prostate Cancer Transformation and Predicts Clinical Recurrence" @default.
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• W1492802015 doi "https://doi.org/10.1002/jcp.24510" @default.
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