FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1492984594> ?p ?o ?g. }

• W1492984594 endingPage "237" @default.
• W1492984594 startingPage "226" @default.
• W1492984594 abstract "Flt3 ligand (FL) is a potent hemopoietic growth factor that strikingly enhances stem cells and dendritic cells (DC) in vivo. We examined the impact of infusing FL-mobilized bone marrow (BM) cells on microchimerism and anti-donor reactivity in normal and tacrolimus-immunosuppressed, noncytoablated allogeneic recipients. BM from B10 (H2b) mice given FL (10 microg/day; days 0-8; FL-BM) contained a 7-fold higher incidence of potentially tolerogenic immature CD11c+ DC (CD40low, CD80low, CD86low, MHC IIlow) that induced alloantigen-specific T cell hyporesponsiveness in vitro. C3H (H2k) mice received 50 x 106 normal or FL-BM cells (day 0) and tacrolimus (2 mg/kg/day; days 0-12). On day 15, enhanced numbers of donor (IAb+) cells were detected in the thymi and spleens of FL-BM recipients. Tacrolimus markedly enhanced microchimerism, which declined as a function of time. Ex vivo splenocyte proliferative and CTL responses and Th1 cytokine (IFN-gamma) production in response to donor alloantigens were augmented by FL-BM infusion, but reduced by tacrolimus. Systemic infusion of purified FL-BM immature DC, equivalent in number to that in corresponding whole BM, confirmed their capacity to sensitize, rather than tolerize, recipient T cells in vivo. In vitro, tacrolimus suppressed GM-CSF-stimulated growth of myeloid DC from normal BM much more effectively than from FL-BM without affecting MHC class II or costimulatory molecule expression. Infusion of normal B10 BM cells at the time of transplant prolonged C3H heart allograft survival, whereas FL-BM cells did not. A therapeutic effect of tacrolimus on graft survival was observed in combination with normal, but not FL-BM cells. These findings suggest the need for alternative immunosuppressive strategies to calcineurin inhibition to enable the engraftment, survival, and immunomodulatory function of FL-enhanced, immature donor DC." @default.
• W1492984594 created "2016-06-24" @default.
• W1492984594 creator A5003254854 @default.
• W1492984594 creator A5043000762 @default.
• W1492984594 creator A5053100074 @default.
• W1492984594 creator A5055043533 @default.
• W1492984594 creator A5059031944 @default.
• W1492984594 creator A5069651723 @default.
• W1492984594 creator A5085858181 @default.
• W1492984594 creator A5090859164 @default.
• W1492984594 date "2000-07-01" @default.
• W1492984594 modified "2023-10-12" @default.
• W1492984594 title "Microchimerism, Donor Dendritic Cells, and Alloimmune Reactivity in Recipients of Flt3 Ligand-Mobilized Hemopoietic Cells: Modulation by Tacrolimus" @default.
• W1492984594 cites W1505013360 @default.
• W1492984594 cites W1514412416 @default.
• W1492984594 cites W154795380 @default.
• W1492984594 cites W1582077486 @default.
• W1492984594 cites W1661544713 @default.
• W1492984594 cites W1948195609 @default.
• W1492984594 cites W1958745508 @default.
• W1492984594 cites W1964261320 @default.
• W1492984594 cites W1967702267 @default.
• W1492984594 cites W1969868671 @default.
• W1492984594 cites W1970198698 @default.
• W1492984594 cites W1981946254 @default.
• W1492984594 cites W1982598733 @default.
• W1492984594 cites W1985641075 @default.
• W1492984594 cites W1987110376 @default.
• W1492984594 cites W1998797990 @default.
• W1492984594 cites W2003466870 @default.
• W1492984594 cites W2009740055 @default.
• W1492984594 cites W2022262230 @default.
• W1492984594 cites W2023367576 @default.
• W1492984594 cites W2028537846 @default.
• W1492984594 cites W2035799558 @default.
• W1492984594 cites W2040572245 @default.
• W1492984594 cites W2040775375 @default.
• W1492984594 cites W2045006755 @default.
• W1492984594 cites W2045882745 @default.
• W1492984594 cites W2054436378 @default.
• W1492984594 cites W2059578322 @default.
• W1492984594 cites W2061393519 @default.
• W1492984594 cites W2062920230 @default.
• W1492984594 cites W2071282292 @default.
• W1492984594 cites W2071432029 @default.
• W1492984594 cites W2085336013 @default.
• W1492984594 cites W2085397716 @default.
• W1492984594 cites W2094607403 @default.
• W1492984594 cites W2100656607 @default.
• W1492984594 cites W2106364131 @default.
• W1492984594 cites W2106883237 @default.
• W1492984594 cites W2111356575 @default.
• W1492984594 cites W2132243512 @default.
• W1492984594 cites W2139705703 @default.
• W1492984594 cites W2146650280 @default.
• W1492984594 cites W2152918507 @default.
• W1492984594 cites W2154455036 @default.
• W1492984594 cites W2155229523 @default.
• W1492984594 cites W2156831625 @default.
• W1492984594 cites W2164838433 @default.
• W1492984594 cites W2166676682 @default.
• W1492984594 cites W2172960056 @default.
• W1492984594 cites W4211138961 @default.
• W1492984594 cites W4241856399 @default.
• W1492984594 cites W4248273573 @default.
• W1492984594 cites W4248923320 @default.
• W1492984594 cites W4249137827 @default.
• W1492984594 doi "https://doi.org/10.4049/jimmunol.165.1.226" @default.
• W1492984594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10861056" @default.
• W1492984594 hasPublicationYear "2000" @default.
• W1492984594 type Work @default.
• W1492984594 sameAs 1492984594 @default.
• W1492984594 citedByCount "30" @default.
• W1492984594 countsByYear W14929845942012 @default.
• W1492984594 countsByYear W14929845942013 @default.
• W1492984594 countsByYear W14929845942014 @default.
• W1492984594 countsByYear W14929845942015 @default.
• W1492984594 countsByYear W14929845942016 @default.
• W1492984594 countsByYear W14929845942018 @default.
• W1492984594 crossrefType "journal-article" @default.
• W1492984594 hasAuthorship W1492984594A5003254854 @default.
• W1492984594 hasAuthorship W1492984594A5043000762 @default.
• W1492984594 hasAuthorship W1492984594A5053100074 @default.
• W1492984594 hasAuthorship W1492984594A5055043533 @default.
• W1492984594 hasAuthorship W1492984594A5059031944 @default.
• W1492984594 hasAuthorship W1492984594A5069651723 @default.
• W1492984594 hasAuthorship W1492984594A5085858181 @default.
• W1492984594 hasAuthorship W1492984594A5090859164 @default.
• W1492984594 hasBestOaLocation W14929845941 @default.
• W1492984594 hasConcept C109159458 @default.
• W1492984594 hasConcept C126322002 @default.
• W1492984594 hasConcept C150903083 @default.
• W1492984594 hasConcept C162834538 @default.
• W1492984594 hasConcept C172680121 @default.
• W1492984594 hasConcept C203014093 @default.
• W1492984594 hasConcept C207001950 @default.
• W1492984594 hasConcept C207936829 @default.
• W1492984594 hasConcept C26291073 @default.

• next