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• W1493008210 abstract "B cells were often thought of as simple precursors of end-stage effector cells that are merely in charge of antibody production. Research in the last decades has shown that B cells possess important other roles as well, including their involvement in the regulation and functioning of T cell-mediated (autoimmune) diseases and host-protective immune responses. This thesis aimed to get a better understanding of the variety of roles B cell subsets play in immune regulation, and how the reciprocal interplay between B- and T cells shapes the outcome of an immune response. Knowledge on how specific B cell subsets influence other players of the immune network provides valuable information that can be used to develop and improve therapies aimed to restore the balance in dysregulated immune systems such as during autoimmunity. Chapter 2 describes research investigating an experimental tolerogenic vaccination strategy. An immunodominant peptide of proteoglycan (PG) was recombinantly fused to a DEC205 endocytic receptor-specific antibody (anti-DEC205-PG). Administration of anti-DEC205-PG delivers PG-peptide to tolerogenic steady-state dendritic cells, and mice prophylactically treated with anti-DEC205-PG do not develop experimental arthritis. Our investigations showed that the DEC205-mediated tolerogenic vaccination resulted in a reduced availability of arthritic PG-specific (follicular) helper T-cells and (temporarily) increased numbers of FoxP3+ regulatory T cells. The amount of B cells participating in germinal centers was subsequently lower as well. Our data suggests that the reduced availability in germinal center-supporting follicular helper T cells eventually limits the production of autoantibodies required for the pathogenesis of arthritis. Chapter 3 and 4 describe research in the immune-regulatory roles of murine peritoneal cavity-derived innate-like B- and B-1a cells when they act either as antigen-presenting cells (APCs) or secrete immunoregulatory cytokines. Chapter 3 shows that peritoneal cavity (PerC) B cells acting as APCs, when compared to splenic B cells, differently activate CD4+ helper T (Th) cells in vitro. Higher percentages of the Th cells activated by PerC B-1a cells possess the ability to secrete the cytokines interferon-γ (IFN-γ), interleukin (IL)-10 and IL-4. This new immunological pathway may be of relevance in vivo, since adoptive transfer experiments showed that peripheral Th cells could be activated locally in the PerC by B-1a cells. Chapter 4 shows that activated PerC B cells produce large amounts of the anti-inflammatory cytokine IL-10. These activated PerC B cells can subsequently function as regulatory B cells (Bregs), since they reduce the amount of Th cells that can produce the pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and IFN-γ in an in vitro Breg-suppression assay. The activation status of PerC B cells turned out to be crucial in this matter, since non-activated PerC B cells increased the amount of TNF-α-producing Th cells instead. Chapter 5 describes an investigation towards the B-cell epitopes on the G1 domain of the joint-derived self-antigen proteoglycan. Our research shows that both proteoglycan-induced arthritic mice and some rheumatoid arthritic patients possess certain antibodies directed against G1-specific B cell epitopes. This knowledge may be useful for the development of new diagnostic tools, e.g., to differentiate clinical subsets of arthritis patients." @default.
• W1493008210 created "2016-06-24" @default.
• W1493008210 creator A5084541931 @default.
• W1493008210 date "2014-03-18" @default.
• W1493008210 modified "2023-09-27" @default.
• W1493008210 title "Bidirectional regulation between B cells and T cells" @default.
• W1493008210 cites W107174851 @default.
• W1493008210 cites W145773090 @default.
• W1493008210 cites W146064790 @default.
• W1493008210 cites W1482572844 @default.
• W1493008210 cites W1487897082 @default.
• W1493008210 cites W1495122617 @default.
• W1493008210 cites W1502867146 @default.
• W1493008210 cites W1503420941 @default.
• W1493008210 cites W1510197257 @default.
• W1493008210 cites W1523039543 @default.
• W1493008210 cites W1526178344 @default.
• W1493008210 cites W1547450219 @default.
• W1493008210 cites W1554784279 @default.
• W1493008210 cites W1556046444 @default.
• W1493008210 cites W1558005320 @default.
• W1493008210 cites W1563439029 @default.
• W1493008210 cites W1573250191 @default.
• W1493008210 cites W1578117262 @default.
• W1493008210 cites W1580698465 @default.
• W1493008210 cites W1586494443 @default.
• W1493008210 cites W1597604585 @default.
• W1493008210 cites W1600867898 @default.
• W1493008210 cites W1639393197 @default.
• W1493008210 cites W1725503312 @default.
• W1493008210 cites W1749491350 @default.
• W1493008210 cites W1753553692 @default.
• W1493008210 cites W1778325192 @default.
• W1493008210 cites W1790240239 @default.
• W1493008210 cites W1799273881 @default.
• W1493008210 cites W1818320070 @default.
• W1493008210 cites W1825135371 @default.
• W1493008210 cites W1832767664 @default.
• W1493008210 cites W186403910 @default.
• W1493008210 cites W1873971399 @default.
• W1493008210 cites W1882149925 @default.
• W1493008210 cites W189264004 @default.
• W1493008210 cites W1905100933 @default.
• W1493008210 cites W1918941126 @default.
• W1493008210 cites W1935840505 @default.
• W1493008210 cites W1955012324 @default.
• W1493008210 cites W1956939804 @default.
• W1493008210 cites W1963701987 @default.
• W1493008210 cites W1965346503 @default.
• W1493008210 cites W1965555677 @default.
• W1493008210 cites W1969632208 @default.
• W1493008210 cites W1970855388 @default.
• W1493008210 cites W1971482083 @default.
• W1493008210 cites W1972715229 @default.
• W1493008210 cites W1977063541 @default.
• W1493008210 cites W1978207888 @default.
• W1493008210 cites W1978431486 @default.
• W1493008210 cites W1978790143 @default.
• W1493008210 cites W1981703286 @default.
• W1493008210 cites W1982094117 @default.
• W1493008210 cites W1982529683 @default.
• W1493008210 cites W1983304157 @default.
• W1493008210 cites W1984531586 @default.
• W1493008210 cites W1986979099 @default.
• W1493008210 cites W1987224476 @default.
• W1493008210 cites W1987474460 @default.
• W1493008210 cites W1990349812 @default.
• W1493008210 cites W1992256920 @default.
• W1493008210 cites W1994042177 @default.
• W1493008210 cites W1995045831 @default.
• W1493008210 cites W1995678458 @default.
• W1493008210 cites W1997462314 @default.
• W1493008210 cites W1998387067 @default.
• W1493008210 cites W1998494804 @default.
• W1493008210 cites W1998766297 @default.
• W1493008210 cites W2000156146 @default.
• W1493008210 cites W2000326189 @default.
• W1493008210 cites W2002116270 @default.
• W1493008210 cites W2002705228 @default.
• W1493008210 cites W2003164422 @default.
• W1493008210 cites W2004382018 @default.
• W1493008210 cites W2004720857 @default.
• W1493008210 cites W2004869330 @default.
• W1493008210 cites W2004914260 @default.
• W1493008210 cites W2006581651 @default.
• W1493008210 cites W2009442193 @default.
• W1493008210 cites W2009501393 @default.
• W1493008210 cites W2011225907 @default.
• W1493008210 cites W2012713313 @default.
• W1493008210 cites W2013278989 @default.
• W1493008210 cites W2014114541 @default.
• W1493008210 cites W2015158428 @default.
• W1493008210 cites W2015945927 @default.
• W1493008210 cites W2019182330 @default.
• W1493008210 cites W2020303255 @default.
• W1493008210 cites W2021158172 @default.
• W1493008210 cites W2021215186 @default.
• W1493008210 cites W2022862336 @default.
• W1493008210 cites W2023502808 @default.
• W1493008210 cites W2024852380 @default.

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