Matches in SemOpenAlex for { <https://semopenalex.org/work/W1493082020> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1493082020 endingPage "459" @default.
- W1493082020 startingPage "455" @default.
- W1493082020 abstract "Clonidine, idazoxan, and related imidazoline adrenergic drugs bind to non-adrenergic sites in brain and several peripheral tissues. These sites, termed imidazoline receptors, appear to exist in two major subclasses, I1 sites labeled by clonidine and I2 sites labeled by idazoxan. In this study, we investigated whether rat prostate expresses imidazoline receptors and, if so, whether their expression can be regulated by circulating testosterone. Studies in rat ventral prostate membrane revealed that [3H]idazoxan, but not [3H]p-aminoclonidine, bound to non-adrenergic sites. The binding of [3H]idazoxan was saturable (Bmax: 941 +/- 105 fmol/mg protein) and high affinity (KD: 16.4 +/- 2.3 nM). The rank order of the inhibition of binding by imidazoline ligands was cirazoline > clonidine > UK 14,304 > guanabenz, indicating an I2 subclass of imidazoline receptors. Bilateral orchiectomy increased the number of binding sites (Bmax) for [3H]idazoxan without changing the affinity (KD). Testosterone replacement, while completely restoring the plasma testosterone levels, only partially reversed the increase in Bmax. In contrast, the binding of [3H]idazoxan to prostate membranes of rats in different age groups (4, 7, and 16 months) revealed a progressive decrease in the Bmax without any change in KD. We conclude that the rat prostate expresses the I2 subclass of imidazoline receptors and that the expression is regulated by circulating testosterone." @default.
- W1493082020 created "2016-06-24" @default.
- W1493082020 creator A5000451293 @default.
- W1493082020 creator A5054313117 @default.
- W1493082020 creator A5055533470 @default.
- W1493082020 creator A5068682755 @default.
- W1493082020 creator A5085264920 @default.
- W1493082020 creator A5086750022 @default.
- W1493082020 date "1996-02-01" @default.
- W1493082020 modified "2023-10-18" @default.
- W1493082020 title "Expression of I2-imidazoline sites in rat prostate" @default.
- W1493082020 cites W1483814123 @default.
- W1493082020 cites W1604272930 @default.
- W1493082020 cites W1966740592 @default.
- W1493082020 cites W1968056243 @default.
- W1493082020 cites W2013464193 @default.
- W1493082020 cites W2018487062 @default.
- W1493082020 cites W2021737715 @default.
- W1493082020 cites W2033067482 @default.
- W1493082020 cites W2037685350 @default.
- W1493082020 cites W2038168669 @default.
- W1493082020 cites W2039311197 @default.
- W1493082020 cites W2043673227 @default.
- W1493082020 cites W2061371011 @default.
- W1493082020 cites W2067268514 @default.
- W1493082020 cites W2076099286 @default.
- W1493082020 cites W2137361061 @default.
- W1493082020 cites W2239654675 @default.
- W1493082020 cites W2417377577 @default.
- W1493082020 doi "https://doi.org/10.1016/0006-2952(95)02201-5" @default.
- W1493082020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8619890" @default.
- W1493082020 hasPublicationYear "1996" @default.
- W1493082020 type Work @default.
- W1493082020 sameAs 1493082020 @default.
- W1493082020 citedByCount "9" @default.
- W1493082020 countsByYear W14930820202012 @default.
- W1493082020 crossrefType "journal-article" @default.
- W1493082020 hasAuthorship W1493082020A5000451293 @default.
- W1493082020 hasAuthorship W1493082020A5054313117 @default.
- W1493082020 hasAuthorship W1493082020A5055533470 @default.
- W1493082020 hasAuthorship W1493082020A5068682755 @default.
- W1493082020 hasAuthorship W1493082020A5085264920 @default.
- W1493082020 hasAuthorship W1493082020A5086750022 @default.
- W1493082020 hasConcept C123605464 @default.
- W1493082020 hasConcept C126322002 @default.
- W1493082020 hasConcept C134018914 @default.
- W1493082020 hasConcept C170493617 @default.
- W1493082020 hasConcept C185592680 @default.
- W1493082020 hasConcept C2776885963 @default.
- W1493082020 hasConcept C2778399450 @default.
- W1493082020 hasConcept C2778680573 @default.
- W1493082020 hasConcept C2778938600 @default.
- W1493082020 hasConcept C2779279991 @default.
- W1493082020 hasConcept C2780648677 @default.
- W1493082020 hasConcept C2780939551 @default.
- W1493082020 hasConcept C71924100 @default.
- W1493082020 hasConcept C86803240 @default.
- W1493082020 hasConceptScore W1493082020C123605464 @default.
- W1493082020 hasConceptScore W1493082020C126322002 @default.
- W1493082020 hasConceptScore W1493082020C134018914 @default.
- W1493082020 hasConceptScore W1493082020C170493617 @default.
- W1493082020 hasConceptScore W1493082020C185592680 @default.
- W1493082020 hasConceptScore W1493082020C2776885963 @default.
- W1493082020 hasConceptScore W1493082020C2778399450 @default.
- W1493082020 hasConceptScore W1493082020C2778680573 @default.
- W1493082020 hasConceptScore W1493082020C2778938600 @default.
- W1493082020 hasConceptScore W1493082020C2779279991 @default.
- W1493082020 hasConceptScore W1493082020C2780648677 @default.
- W1493082020 hasConceptScore W1493082020C2780939551 @default.
- W1493082020 hasConceptScore W1493082020C71924100 @default.
- W1493082020 hasConceptScore W1493082020C86803240 @default.
- W1493082020 hasIssue "4" @default.
- W1493082020 hasLocation W14930820201 @default.
- W1493082020 hasLocation W14930820202 @default.
- W1493082020 hasOpenAccess W1493082020 @default.
- W1493082020 hasPrimaryLocation W14930820201 @default.
- W1493082020 hasRelatedWork W1493082020 @default.
- W1493082020 hasRelatedWork W1978236712 @default.
- W1493082020 hasRelatedWork W1998680340 @default.
- W1493082020 hasRelatedWork W2015981982 @default.
- W1493082020 hasRelatedWork W2033840897 @default.
- W1493082020 hasRelatedWork W2043218865 @default.
- W1493082020 hasRelatedWork W2050868261 @default.
- W1493082020 hasRelatedWork W2063451248 @default.
- W1493082020 hasRelatedWork W2318073724 @default.
- W1493082020 hasRelatedWork W2409120157 @default.
- W1493082020 hasVolume "51" @default.
- W1493082020 isParatext "false" @default.
- W1493082020 isRetracted "false" @default.
- W1493082020 magId "1493082020" @default.
- W1493082020 workType "article" @default.