Matches in SemOpenAlex for { <https://semopenalex.org/work/W1493109520> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1493109520 endingPage "104" @default.
- W1493109520 startingPage "97" @default.
- W1493109520 abstract "1.|The amino groups of the lysine residues of ovine luteinizing hormone were modified by reductive alkylation, guanidination and carbamylation. The degree of modification obtained was examined and the biological activity of the derivatives was investigated. 2.|When reductive methylation was performed on native luteinizing hormone, only 50% of the lysine-20 residue in the β-subunit was methylated, showing that this residue is less accessible than the lysine-42 (90% methylated). 3.|Abolition of the positive charges of half the lysine residues of luteinizing hormone (by carbamylation) led to the loss of biological activity, whereas guanidination or methylation produced active derivatives. Isopropylated luteinizing hormone was, on the contrary, almost inactive, probably as a consequence of the elongation of the alkyl chain. Directly methylated luteinizing hormone was more active in the Parlow test than was native luteinizing hormone, whereas reconstituted luteinizing hormone obtained by recombination of an intact subunit with a methylated subunit was less active than native luteinizing hormone or that obtained by recombination of two normal subunits. On the basis of these results the relationship between structure and the biological activity of luteinizing hormone is discussed." @default.
- W1493109520 created "2016-06-24" @default.
- W1493109520 creator A5014203085 @default.
- W1493109520 creator A5017332118 @default.
- W1493109520 creator A5058352789 @default.
- W1493109520 creator A5090257154 @default.
- W1493109520 date "1974-03-01" @default.
- W1493109520 modified "2023-10-15" @default.
- W1493109520 title "Chemical modification of lysine residues in ovine luteinizing hormone" @default.
- W1493109520 cites W1554175843 @default.
- W1493109520 cites W1964943989 @default.
- W1493109520 cites W1977093640 @default.
- W1493109520 cites W1989090188 @default.
- W1493109520 cites W2002711833 @default.
- W1493109520 cites W2009277200 @default.
- W1493109520 cites W2009842635 @default.
- W1493109520 cites W2022862517 @default.
- W1493109520 cites W2032067145 @default.
- W1493109520 cites W2040101762 @default.
- W1493109520 cites W2048768181 @default.
- W1493109520 cites W2057470822 @default.
- W1493109520 cites W2058007854 @default.
- W1493109520 cites W2059132791 @default.
- W1493109520 cites W2060102409 @default.
- W1493109520 cites W2077533017 @default.
- W1493109520 cites W2080983109 @default.
- W1493109520 cites W2082088856 @default.
- W1493109520 cites W2087844845 @default.
- W1493109520 cites W2093416481 @default.
- W1493109520 cites W2412102098 @default.
- W1493109520 cites W4256543305 @default.
- W1493109520 cites W61918926 @default.
- W1493109520 doi "https://doi.org/10.1016/0005-2795(74)90110-x" @default.
- W1493109520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4824929" @default.
- W1493109520 hasPublicationYear "1974" @default.
- W1493109520 type Work @default.
- W1493109520 sameAs 1493109520 @default.
- W1493109520 citedByCount "41" @default.
- W1493109520 crossrefType "journal-article" @default.
- W1493109520 hasAuthorship W1493109520A5014203085 @default.
- W1493109520 hasAuthorship W1493109520A5017332118 @default.
- W1493109520 hasAuthorship W1493109520A5058352789 @default.
- W1493109520 hasAuthorship W1493109520A5090257154 @default.
- W1493109520 hasConcept C104292427 @default.
- W1493109520 hasConcept C104317684 @default.
- W1493109520 hasConcept C116073593 @default.
- W1493109520 hasConcept C161790260 @default.
- W1493109520 hasConcept C164361826 @default.
- W1493109520 hasConcept C185592680 @default.
- W1493109520 hasConcept C202751555 @default.
- W1493109520 hasConcept C2776016237 @default.
- W1493109520 hasConcept C2778575703 @default.
- W1493109520 hasConcept C2781338088 @default.
- W1493109520 hasConcept C33288867 @default.
- W1493109520 hasConcept C515207424 @default.
- W1493109520 hasConcept C552990157 @default.
- W1493109520 hasConcept C55493867 @default.
- W1493109520 hasConcept C71240020 @default.
- W1493109520 hasConcept C71315377 @default.
- W1493109520 hasConceptScore W1493109520C104292427 @default.
- W1493109520 hasConceptScore W1493109520C104317684 @default.
- W1493109520 hasConceptScore W1493109520C116073593 @default.
- W1493109520 hasConceptScore W1493109520C161790260 @default.
- W1493109520 hasConceptScore W1493109520C164361826 @default.
- W1493109520 hasConceptScore W1493109520C185592680 @default.
- W1493109520 hasConceptScore W1493109520C202751555 @default.
- W1493109520 hasConceptScore W1493109520C2776016237 @default.
- W1493109520 hasConceptScore W1493109520C2778575703 @default.
- W1493109520 hasConceptScore W1493109520C2781338088 @default.
- W1493109520 hasConceptScore W1493109520C33288867 @default.
- W1493109520 hasConceptScore W1493109520C515207424 @default.
- W1493109520 hasConceptScore W1493109520C552990157 @default.
- W1493109520 hasConceptScore W1493109520C55493867 @default.
- W1493109520 hasConceptScore W1493109520C71240020 @default.
- W1493109520 hasConceptScore W1493109520C71315377 @default.
- W1493109520 hasIssue "1" @default.
- W1493109520 hasLocation W14931095201 @default.
- W1493109520 hasLocation W14931095202 @default.
- W1493109520 hasOpenAccess W1493109520 @default.
- W1493109520 hasPrimaryLocation W14931095201 @default.
- W1493109520 hasRelatedWork W1991597513 @default.
- W1493109520 hasRelatedWork W2094940428 @default.
- W1493109520 hasRelatedWork W2097827269 @default.
- W1493109520 hasRelatedWork W2112203803 @default.
- W1493109520 hasRelatedWork W2435489378 @default.
- W1493109520 hasRelatedWork W2942948112 @default.
- W1493109520 hasRelatedWork W2949467820 @default.
- W1493109520 hasRelatedWork W2951116329 @default.
- W1493109520 hasRelatedWork W4289968949 @default.
- W1493109520 hasRelatedWork W4318374246 @default.
- W1493109520 hasVolume "342" @default.
- W1493109520 isParatext "false" @default.
- W1493109520 isRetracted "false" @default.
- W1493109520 magId "1493109520" @default.
- W1493109520 workType "article" @default.