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- W1493129265 abstract "Abstract This work examines the fabrication regime and the properties of polymer–enzyme thin‐films adsorbed onto conductive substrates (graphite or gold). The films are formed via two‐steps, sequential adsorption of poly( n ‐butylmethacrylate)‐ block ‐poly( N,N‐ dimethylaminoethyl methacrylate) (P n BMA‐ b ‐PDMAEMA) diblock copolymer micelles (1st step of adsorption), followed by the enzyme choline oxidase (ChO) (2nd step of adsorption). The solution properties of both adsorbed components are studied and the pH‐dependent step‐by‐step fabrication of polymer–enzyme biosensor coatings reveals rather drastic differences in their enzymatic activities in dependence on the pH of both adsorption steps. The resulting hybrid thin‐films represent highly active biosensors for choline with a low detection limit of 30 n M and a good linearity in a range between 30 n M and 100 μ M . The sensitivity is found to be 175 μA m M −1 cm −2 and the operational stability of the polymer–enzyme thin‐films can be additionally improved via enzyme‐to‐enzyme crosslinking with glutaraldehyde." @default.
- W1493129265 created "2016-06-24" @default.
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- W1493129265 date "2014-04-17" @default.
- W1493129265 modified "2023-10-17" @default.
- W1493129265 title "Sequential pH-Dependent Adsorption of Ionic Amphiphilic Diblock Copolymer Micelles and Choline Oxidase Onto Conductive Substrates: Toward the Design of Biosensors" @default.
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- W1493129265 doi "https://doi.org/10.1002/mabi.201300580" @default.
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