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- W1493145632 abstract "The epithelium of the respiratory tract forms a large surface area that maintains intimate contact with the environment. Through the act of breathing, this mucosal surface encounters an array of pathogens and toxic particulates. In response to these challenges many strategies have evolved to protect the host. These include the barrier functions of the epithelium, cough, mucociliary clearance, resident professional phagocytes, and the secretion of a number of proteins and peptides with host defense functions (Bartlett et al., 2008). The respiratory epithelium is lined with cilia that normally carry out an integrated and coordinated mechanism called mucociliary clearance. Mucociliary clearance, the process by which cilia transport the viscous mucus blanket of the upper airway to the gastrointestinal tract, is the primary means by which the upper airway clears itself of pathogens, allergens, debris, and toxins. Cilia are evolutionarily conserved structures that play a role in diverse cell types. Cilia are complex and powerful cellular structures that serve a multitude of functions across many types of organisms. In humans, one of the most critical roles of cilia is defense of the airway. The complex structure and regulatory mechanisms that dictate the form and function of normal cilia are not entirely understood, but it is clear that ciliary dysfunction results in impaired respiratory defense. Ciliary dysfunction may be primary, the result of genetic mutations resulting in abnormal cilia structure, or secondary, the result of environmental, infectious or inflammatory stimuli that disrupt normal motility or coordination." @default.
- W1493145632 created "2016-06-24" @default.
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- W1493145632 date "2011-10-17" @default.
- W1493145632 modified "2023-10-03" @default.
- W1493145632 title "Primary Ciliary Dyskinesia/Kartagener Syndrome - Clinical and Genetic Aspects" @default.
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- W1493145632 doi "https://doi.org/10.5772/16772" @default.
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