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• W1493255043 abstract "Metastases to the brain is one of the most feared complication of systemic cancer and its incidence is rising for several reasons. The two most important reasons are the improvement in treatment, with a longer patient life; and the advance in diagnostic and imaging means Magnetic Resonance Image (MRI) and Computed Tomography (CT), Positron Emission Tomography [PET]) that have permitted to detect smaller lesions in asymptomatic patients. These improvement in radiology allows earlier diagnosis and result in better treatment management (Kamar et al., 2010, Rao et al, 2007, Patchell et al. 2003). Single metastases are detected in greater proportion. For example, in the case of ovarian tumors brain metastases are solitary in 43% of the cases (Pectasides et al. 2006). Single metastases appear approximately in one quarter of all patients with brain metastases (Rao et al. 2007). Norden et al. 2005 recently reported that breast, colon and renal cell carcinoma tend to produce single metastases, whereas melanoma and lung cancer have a greater tendency to produce multiple metastases. Single metastases can be treated surgically or by high precise radiotherapy modalities such as Gamma knife and StereoTactic Radiotherapy (SRT) or Conformal Radiotherapy (CRT). SRT was initially used for substituting surgical approach in patients with inaccessible tumor location or with comorbid medical conditions, now is used in many institutions as first approach, peculiarly from breast colon and renal carcinoma. Actually, many patients, refuse surgical approach so the use of SRT or CRT in combination with whole brain irradiation (WBRT) or SRT as a boosting method after WBRT is increasing. Associated to radiotherapy and chemotherapy we suggest and discuss the biological reasons for adding hyperthermia and glycolysis metabolic inhibitors with the aim to obtain a better control of brain metastases." @default.
• W1493255043 created "2016-06-24" @default.
• W1493255043 creator A5016012559 @default.
• W1493255043 creator A5029721709 @default.
• W1493255043 creator A5055489524 @default.
• W1493255043 date "2011-11-21" @default.
• W1493255043 modified "2023-09-25" @default.
• W1493255043 title "Brain Metastases: Biology and Comprehensive Strategy from Radiotherapy to Metabolic Inhibitors and Hyperthermia" @default.
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