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- W1493291210 abstract "Two classes of drugs, antiretrovirals andantibiotics, could benefit greatly from delivery throughmicroneedles. Microneedles (MN) offer an increase in efficacy forthese drugs by providing delivery to the lymphatic system throughthe skin, thus avoiding first pass metabolism and allowing morefocused delivery to specific viral or bacterial reservoirs.Furthermore, microneedles present other advantages in the form ofthe ability to be self-administered, tunable controlled release,and painless administration. Saquinavir and Ciprofloxacin, anantiretroviral and an antibiotic respectively, were chosen fortheir optimal properties, including bioavailability, half-life, anddosage. Saquinavir was encapsulated in the organic phase ofbiodegradable poly(lactide-co-glycolide) microparticles (MP)synthesized through a double emulsion. Similarly, Ciprofloxacin wasencapsulated in the aqueous phase of the microparticles. Inaddition, Ciprofloxacin microcrystals were synthesized. Themicroparticles and microcrystals were then loaded into moldedpolymer microneedles in a poly-acrylic acid (PAA) matrix. Standardcurves were created for the two drugs from known concentrations andused to show the drug loading in the microparticles andmicroneedles. The Saquinavir microparticles showed a maximumloading of 1.35% the mass of particles and the Ciprofloxacinmicroparticles showed a maximum loading of 0.197%. The Saquinavirmicroparticle microneedles had a maximum loading of 11.95 [mu]g ofSaquinavir per 1 cm² array and the Ciprofloxacin microparticlemicroneedles had a maximum loading of .41 [mu]g of Ciprofloxacinper 1 cm² array. The Ciprofloxacin microcrystal microneedlees had amaximum loading of 165 [mu]g per 1 cm² array. Analysis based oninsulin delivery through microneedles showed these loadings to betoo low to create the sufficient minimum drug concentration inplasma. However, there exist multiple strategies to increase theloading of the drugs in the microneedles. These results provedpromising for the use of microneedles for the delivery ofantiretroviral and antibiotic drugs." @default.
- W1493291210 created "2016-06-24" @default.
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- W1493291210 date "2012-01-01" @default.
- W1493291210 modified "2023-09-24" @default.
- W1493291210 title "Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs" @default.
- W1493291210 hasPublicationYear "2012" @default.
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