Matches in SemOpenAlex for { <https://semopenalex.org/work/W1493291278> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W1493291278 endingPage "143" @default.
- W1493291278 startingPage "127" @default.
- W1493291278 abstract "Organization of the cortical cytoplasm during the syncytial blastoderm stages of early Drosophila embryogenesis relies on cyclic transitions between transient microfilament structures. Microtubule-organizing centres (MTOCs) appear to provide the instructive cues governing this dynamic, cell-cycle-dependent process. Using a genetic approach, we have identified key roles for two molecular pathways in mediating these events. The conserved Arp2/3 microfilament nucleation machinery, likely acting in response to the activating element SCAR, plays an essential role in establishment of a cortical F-actin array, and contributes to specific aspects of cyclic microfilament restructuring. Defective cortical microfilament organization is the primary phenotypic feature of embryos derived from mothers bearing mutations in the sponge locus. Several lines of investigation suggest that the primary defect in sponge lies in a faulty cortical microfilament response, downstream of the centrosomal signal. We have determined that sponge encodes a Drosophila homologue of the evolutionarily-conserved CDM (DOCK180) protein family." @default.
- W1493291278 created "2016-06-24" @default.
- W1493291278 creator A5021778634 @default.
- W1493291278 date "2005-09-09" @default.
- W1493291278 modified "2023-10-18" @default.
- W1493291278 title "Actin Organization in the Early Drosophila Embryo" @default.
- W1493291278 doi "https://doi.org/10.1002/047001766x.ch11" @default.
- W1493291278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16355538" @default.
- W1493291278 hasPublicationYear "2005" @default.
- W1493291278 type Work @default.
- W1493291278 sameAs 1493291278 @default.
- W1493291278 citedByCount "1" @default.
- W1493291278 countsByYear W14932912782021 @default.
- W1493291278 crossrefType "other" @default.
- W1493291278 hasAuthorship W1493291278A5021778634 @default.
- W1493291278 hasConcept C125705527 @default.
- W1493291278 hasConcept C129536746 @default.
- W1493291278 hasConcept C142669718 @default.
- W1493291278 hasConcept C1491633281 @default.
- W1493291278 hasConcept C189040839 @default.
- W1493291278 hasConcept C196843134 @default.
- W1493291278 hasConcept C20418707 @default.
- W1493291278 hasConcept C54355233 @default.
- W1493291278 hasConcept C86803240 @default.
- W1493291278 hasConcept C87073359 @default.
- W1493291278 hasConcept C95444343 @default.
- W1493291278 hasConcept C98535976 @default.
- W1493291278 hasConceptScore W1493291278C125705527 @default.
- W1493291278 hasConceptScore W1493291278C129536746 @default.
- W1493291278 hasConceptScore W1493291278C142669718 @default.
- W1493291278 hasConceptScore W1493291278C1491633281 @default.
- W1493291278 hasConceptScore W1493291278C189040839 @default.
- W1493291278 hasConceptScore W1493291278C196843134 @default.
- W1493291278 hasConceptScore W1493291278C20418707 @default.
- W1493291278 hasConceptScore W1493291278C54355233 @default.
- W1493291278 hasConceptScore W1493291278C86803240 @default.
- W1493291278 hasConceptScore W1493291278C87073359 @default.
- W1493291278 hasConceptScore W1493291278C95444343 @default.
- W1493291278 hasConceptScore W1493291278C98535976 @default.
- W1493291278 hasLocation W14932912781 @default.
- W1493291278 hasLocation W14932912782 @default.
- W1493291278 hasOpenAccess W1493291278 @default.
- W1493291278 hasPrimaryLocation W14932912781 @default.
- W1493291278 hasRelatedWork W1531816097 @default.
- W1493291278 hasRelatedWork W1976433348 @default.
- W1493291278 hasRelatedWork W1998274339 @default.
- W1493291278 hasRelatedWork W2039495782 @default.
- W1493291278 hasRelatedWork W2061887935 @default.
- W1493291278 hasRelatedWork W2081451190 @default.
- W1493291278 hasRelatedWork W2352927845 @default.
- W1493291278 hasRelatedWork W2414574994 @default.
- W1493291278 hasRelatedWork W2471276139 @default.
- W1493291278 hasRelatedWork W4245474806 @default.
- W1493291278 isParatext "false" @default.
- W1493291278 isRetracted "false" @default.
- W1493291278 magId "1493291278" @default.
- W1493291278 workType "other" @default.