FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1493322929> ?p ?o ?g. }

• W1493322929 endingPage "3104" @default.
• W1493322929 startingPage "3093" @default.
• W1493322929 abstract "Oxysterols, and particularly 7-ketocholesterol, appear to be strongly involved in the physiopathology of atherosclerosis. These molecules are suspected to be cytotoxic to the cells of the vascular wall and monocytes/macrophages, particularly by inducing apoptosis. Previous studies have demonstrated that 7-ketocholesterol-induced apoptosis is triggered by a sustained increase of cytosolic-free Ca2+, which elicits the mitochondrial pathway of apoptosis by activation of the calcium-dependent phosphatase calcineurin, leading to dephosphorylation of the 'BH3 only' protein BAD. However, thorough study of the results suggests that other pathways are implicated in 7-ketocholesterol-induced cytotoxicity. In this study, we demonstrate the involvement of two other calcium-dependent pathways during 7-ketocholesterol-induced apoptosis. The activation of the MEK-->ERK pathway by the calcium-dependent tyrosine kinase PYK 2, a survival pathway which delays apoptosis as shown by the use of the MEK inhibitor U0126, and a pathway involving another pro-apoptotic BH3 only protein, Bim. Indeed, 7-ketocholesterol treatment of human monocytic THP-1 cells induces the release of Bim-LC8 from the microtubule-associated dynein motor complex, and its association with Bcl-2. Therefore, it appears that 7-ketocholesterol-induced apoptosis is a complex phenomenon resulting from calcium-dependent activation of several pro-apoptotic pathways and also one survival pathway." @default.
• W1493322929 created "2016-06-24" @default.
• W1493322929 creator A5002032049 @default.
• W1493322929 creator A5026218828 @default.
• W1493322929 creator A5042444179 @default.
• W1493322929 creator A5044053790 @default.
• W1493322929 creator A5048082636 @default.
• W1493322929 creator A5048915129 @default.
• W1493322929 creator A5051287108 @default.
• W1493322929 creator A5057859741 @default.
• W1493322929 creator A5065348204 @default.
• W1493322929 creator A5083829012 @default.
• W1493322929 date "2005-06-01" @default.
• W1493322929 modified "2023-10-17" @default.
• W1493322929 title "7-Ketocholesterol-induced apoptosis" @default.
• W1493322929 cites W1924066642 @default.
• W1493322929 cites W1965394772 @default.
• W1493322929 cites W1970189293 @default.
• W1493322929 cites W1974547108 @default.
• W1493322929 cites W1975857526 @default.
• W1493322929 cites W1976441097 @default.
• W1493322929 cites W1978798502 @default.
• W1493322929 cites W1979938844 @default.
• W1493322929 cites W1981166298 @default.
• W1493322929 cites W1987035130 @default.
• W1493322929 cites W1990218498 @default.
• W1493322929 cites W1996644939 @default.
• W1493322929 cites W1999788892 @default.
• W1493322929 cites W2005909927 @default.
• W1493322929 cites W2012543314 @default.
• W1493322929 cites W2014280822 @default.
• W1493322929 cites W2016870402 @default.
• W1493322929 cites W2017339165 @default.
• W1493322929 cites W2017813763 @default.
• W1493322929 cites W2018695514 @default.
• W1493322929 cites W2025595974 @default.
• W1493322929 cites W2026213230 @default.
• W1493322929 cites W2042252937 @default.
• W1493322929 cites W2054998458 @default.
• W1493322929 cites W2056527670 @default.
• W1493322929 cites W2069132844 @default.
• W1493322929 cites W2076710136 @default.
• W1493322929 cites W2079051863 @default.
• W1493322929 cites W2086918192 @default.
• W1493322929 cites W2098130258 @default.
• W1493322929 cites W2101950671 @default.
• W1493322929 cites W2103363752 @default.
• W1493322929 cites W2107528191 @default.
• W1493322929 cites W2113574245 @default.
• W1493322929 cites W2138432486 @default.
• W1493322929 cites W2146983373 @default.
• W1493322929 cites W2157740207 @default.
• W1493322929 cites W2187707360 @default.
• W1493322929 cites W2320950260 @default.
• W1493322929 cites W2418219962 @default.
• W1493322929 cites W4232534952 @default.
• W1493322929 cites W4241583276 @default.
• W1493322929 doi "https://doi.org/10.1111/j.1742-4658.2005.04723.x" @default.
• W1493322929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15955068" @default.
• W1493322929 hasPublicationYear "2005" @default.
• W1493322929 type Work @default.
• W1493322929 sameAs 1493322929 @default.
• W1493322929 citedByCount "85" @default.
• W1493322929 countsByYear W14933229292012 @default.
• W1493322929 countsByYear W14933229292013 @default.
• W1493322929 countsByYear W14933229292014 @default.
• W1493322929 countsByYear W14933229292015 @default.
• W1493322929 countsByYear W14933229292016 @default.
• W1493322929 countsByYear W14933229292017 @default.
• W1493322929 countsByYear W14933229292018 @default.
• W1493322929 countsByYear W14933229292019 @default.
• W1493322929 countsByYear W14933229292020 @default.
• W1493322929 countsByYear W14933229292021 @default.
• W1493322929 countsByYear W14933229292023 @default.
• W1493322929 crossrefType "journal-article" @default.
• W1493322929 hasAuthorship W1493322929A5002032049 @default.
• W1493322929 hasAuthorship W1493322929A5026218828 @default.
• W1493322929 hasAuthorship W1493322929A5042444179 @default.
• W1493322929 hasAuthorship W1493322929A5044053790 @default.
• W1493322929 hasAuthorship W1493322929A5048082636 @default.
• W1493322929 hasAuthorship W1493322929A5048915129 @default.
• W1493322929 hasAuthorship W1493322929A5051287108 @default.
• W1493322929 hasAuthorship W1493322929A5057859741 @default.
• W1493322929 hasAuthorship W1493322929A5065348204 @default.
• W1493322929 hasAuthorship W1493322929A5083829012 @default.
• W1493322929 hasBestOaLocation W14933229291 @default.
• W1493322929 hasConcept C11960822 @default.
• W1493322929 hasConcept C126322002 @default.
• W1493322929 hasConcept C128057223 @default.
• W1493322929 hasConcept C178666793 @default.
• W1493322929 hasConcept C178790620 @default.
• W1493322929 hasConcept C181199279 @default.
• W1493322929 hasConcept C181912034 @default.
• W1493322929 hasConcept C184235292 @default.
• W1493322929 hasConcept C185592680 @default.
• W1493322929 hasConcept C190283241 @default.
• W1493322929 hasConcept C201571599 @default.
• W1493322929 hasConcept C2911091166 @default.

• next