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- W1493561953 abstract "Abstract The functional heterogeneity of human lymphokine-activated killer (LAK) cells was characterized using LAK effector cells generated in vivo during rIL-2 therapy and separated by FACS into Leu 19bright+ and Leu 19dim+ subsets. The Leu 19bright+ subset mediated significantly greater levels of LAK lytic activity against NK-resistant COLO 205 target cells compared to Leu 19dim+ effector cells in chromium release assays. Single cell cytotoxicity assays showed that the Leu 19bright+ LAK effector cell subset contained a significantly higher percentage of cells capable of binding to and lysing COLO 205 or K562 target cells compared to the Leu 19dim+ subset. Furthermore, individual Leu 19bright+ LAK effector cells exhibited a more rapid rate of COLO 205 target cell lysis when compared to Leu 19dim+ LAK effector cells. In vitro culturing of Leu 19bright+ or Leu 19dim+ cells from normal donors with 1500 U/ml rIL-2 resulted in significantly greater levels of proliferation and LAK effector activity by Leu 19bright+ cells. Furthermore, whereas 86% of normal Leu 19bright+ cells maintained a Leu 19bright+ phenotype after rIL-2 stimulation, only 24% of Leu 19dim+ cells developed a Leu 19bright+ phenotype. These data demonstrate that Leu 19bright+ LAK cells are significantly more potent effectors than Leu 19dim+ cells due to quantitative and qualitative differences in the LAK effector cells contained within these subsets. Furthermore, these data indicate that Leu 19bright+ LAK cells that develop during rIL-2 therapy are derived from Leu 19bright+ precursor cells." @default.
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- W1493561953 date "1989-04-15" @default.
- W1493561953 modified "2023-10-15" @default.
- W1493561953 title "Functional heterogeneity of Leu 19bright+ and Leu 19dim+ lymphokine-activated killer cells." @default.
- W1493561953 doi "https://doi.org/10.4049/jimmunol.142.8.2949" @default.
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