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- W1493584987 endingPage "558" @default.
- W1493584987 startingPage "547" @default.
- W1493584987 abstract "Hedgehog (Hh) signaling has emerged in recent years as an attractive target for anticancer therapy because its aberrant activation is implicated in several cancers. Major progress has been made in the development of SMOOTHENED (SMO) antagonists, although they have shown several limitations due to downstream SMO pathway activation or the occurrence of drug-resistant SMO mutations. Recently, particular interest has been elicited by the identification of molecules able to hit glioma-associated oncogene (GLI) factors, the final effectors of the Hh pathway, which provide a valid tool to overcome anti-SMO resistance. Here, we review results achieved in developing GLI antagonists, explaining their mechanisms of action and highlighting their therapeutic potential. We also underline the relevance of structural details in their discovery and optimization." @default.
- W1493584987 created "2016-06-24" @default.
- W1493584987 creator A5012691987 @default.
- W1493584987 creator A5043651452 @default.
- W1493584987 creator A5044346256 @default.
- W1493584987 creator A5071370272 @default.
- W1493584987 creator A5086731068 @default.
- W1493584987 date "2015-08-01" @default.
- W1493584987 modified "2023-10-02" @default.
- W1493584987 title "Targeting GLI factors to inhibit the Hedgehog pathway" @default.
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