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- W1493612826 abstract "Abstract Induction of functional memory cytotoxic T lymphocytes (CTLs) holds promise for fighting critical infectious diseases through vaccination, but so far, no effective regime has been identified. One round of immunization is normally not sufficient for generating functional memory CTLs, and subsequent boosting is required. We show here that repetitive intravenous boosting with peptide and adjuvant following priming progressively enhances memory CTLs and drives their differentiation to a unique and long-lasting effector memory phenotype characterized by decreased interferon-γ but increased granzyme B production. The resulting memory CTLs are clearly not immune senescent but are functional and able to provide protection against pathogen challenge. Furthermore, similar enhancement of functional memory CTLs can be achieved regardless of the adjuvant used. Overall, our results suggest that intravenous peptide boosting with adjuvant following priming may be a viable method for generating long-term functional memory CTLs through vaccination." @default.
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- W1493612826 date "2012-05-01" @default.
- W1493612826 modified "2023-09-23" @default.
- W1493612826 title "Repetitive peptide boosting induces functional memory cytotoxic T lymphocytes of a new phenotype (122.4)" @default.
- W1493612826 doi "https://doi.org/10.4049/jimmunol.188.supp.122.4" @default.
- W1493612826 hasPublicationYear "2012" @default.
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