Matches in SemOpenAlex for { <https://semopenalex.org/work/W1493707960> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1493707960 endingPage "6547" @default.
- W1493707960 startingPage "6541" @default.
- W1493707960 abstract "Taxol has been known to block cell division by stabilizing microtubules with promising anticancer activity. However, taxol has distinct cell cycle-independent effects. Recently, this novel drug has been shown to provide a second signal for murine macrophage activation to tumoricidal activity via L-arginine-dependent nitric oxide (NO) synthesis. To investigate the mechanism of taxol-induced NO synthesis, we evaluated the ability of protein kinase C (PKC) inhibitors such as staurosporine (STSN) or polymyxin B to block taxol-induced effects. Taxol alone had only a small effect, whereas taxol in combination with rIFN-gamma markedly increased NO synthesis in a dose-dependent manner. STSN and polymyxin B decreased NO synthesis, which had been induced by rIFN-gamma plus taxol. Furthermore, prolonged incubation of the cells with phorbol ester, which down-regulates PKC activity, abolished synergistic cooperative effect of taxol with rIFN-gamma on NO synthesis. Synergy between IFN-gamma and taxol was mainly dependent on taxol-induced TNF-alpha secretion because not only the increase of inducible NO synthase (iNOS) gene expression by rIFN-gamma plus taxol was associated with the increased expression of TNF-alpha gene but also taxol-induced NO production was decreased by the treatment of anti-murine TNF-alpha neutralizing Abs. STSN and polymyxin B potently inhibited taxol-induced TNF-alpha secretion and TNF-alpha gene expression as well as iNOS gene expression by rIFN-gamma plus taxol. However, rIFN-gamma plus TNF-alpha-induced NO synthesis was not blocked by STSN or polymyxin B. This result indicates that TNF-alpha-induced signaling for induction of NO synthesis is not dependent on PKC activation, and further suggests that the point at which TNF-alpha acts on the NO synthesis from rIFN-gamma-primed macrophages lies next to the point of PKC activation. In conclusion, the present results strongly suggest that the capacity of taxol to increase NO synthesis from rIFN-gamma-primed macrophages is the result of taxol-induced TNF-alpha secretion via the signal transduction pathway of PKC activation." @default.
- W1493707960 created "2016-06-24" @default.
- W1493707960 creator A5025988781 @default.
- W1493707960 creator A5046129212 @default.
- W1493707960 creator A5055589381 @default.
- W1493707960 creator A5074115262 @default.
- W1493707960 date "1995-06-15" @default.
- W1493707960 modified "2023-10-06" @default.
- W1493707960 title "Involvement of protein kinase C during taxol-induced activation of murine peritoneal macrophages." @default.
- W1493707960 doi "https://doi.org/10.4049/jimmunol.154.12.6541" @default.
- W1493707960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7759887" @default.
- W1493707960 hasPublicationYear "1995" @default.
- W1493707960 type Work @default.
- W1493707960 sameAs 1493707960 @default.
- W1493707960 citedByCount "54" @default.
- W1493707960 countsByYear W14937079602013 @default.
- W1493707960 countsByYear W14937079602014 @default.
- W1493707960 countsByYear W14937079602015 @default.
- W1493707960 countsByYear W14937079602016 @default.
- W1493707960 countsByYear W14937079602018 @default.
- W1493707960 countsByYear W14937079602019 @default.
- W1493707960 countsByYear W14937079602021 @default.
- W1493707960 countsByYear W14937079602022 @default.
- W1493707960 crossrefType "journal-article" @default.
- W1493707960 hasAuthorship W1493707960A5025988781 @default.
- W1493707960 hasAuthorship W1493707960A5046129212 @default.
- W1493707960 hasAuthorship W1493707960A5055589381 @default.
- W1493707960 hasAuthorship W1493707960A5074115262 @default.
- W1493707960 hasBestOaLocation W14937079601 @default.
- W1493707960 hasConcept C104317684 @default.
- W1493707960 hasConcept C134018914 @default.
- W1493707960 hasConcept C150194340 @default.
- W1493707960 hasConcept C153911025 @default.
- W1493707960 hasConcept C17991360 @default.
- W1493707960 hasConcept C184235292 @default.
- W1493707960 hasConcept C185592680 @default.
- W1493707960 hasConcept C195794163 @default.
- W1493707960 hasConcept C203014093 @default.
- W1493707960 hasConcept C2779084600 @default.
- W1493707960 hasConcept C2780026444 @default.
- W1493707960 hasConcept C501593827 @default.
- W1493707960 hasConcept C519581460 @default.
- W1493707960 hasConcept C55493867 @default.
- W1493707960 hasConcept C86803240 @default.
- W1493707960 hasConcept C98274493 @default.
- W1493707960 hasConceptScore W1493707960C104317684 @default.
- W1493707960 hasConceptScore W1493707960C134018914 @default.
- W1493707960 hasConceptScore W1493707960C150194340 @default.
- W1493707960 hasConceptScore W1493707960C153911025 @default.
- W1493707960 hasConceptScore W1493707960C17991360 @default.
- W1493707960 hasConceptScore W1493707960C184235292 @default.
- W1493707960 hasConceptScore W1493707960C185592680 @default.
- W1493707960 hasConceptScore W1493707960C195794163 @default.
- W1493707960 hasConceptScore W1493707960C203014093 @default.
- W1493707960 hasConceptScore W1493707960C2779084600 @default.
- W1493707960 hasConceptScore W1493707960C2780026444 @default.
- W1493707960 hasConceptScore W1493707960C501593827 @default.
- W1493707960 hasConceptScore W1493707960C519581460 @default.
- W1493707960 hasConceptScore W1493707960C55493867 @default.
- W1493707960 hasConceptScore W1493707960C86803240 @default.
- W1493707960 hasConceptScore W1493707960C98274493 @default.
- W1493707960 hasIssue "12" @default.
- W1493707960 hasLocation W14937079601 @default.
- W1493707960 hasLocation W14937079602 @default.
- W1493707960 hasOpenAccess W1493707960 @default.
- W1493707960 hasPrimaryLocation W14937079601 @default.
- W1493707960 hasRelatedWork W1987122807 @default.
- W1493707960 hasRelatedWork W1997612327 @default.
- W1493707960 hasRelatedWork W2001141752 @default.
- W1493707960 hasRelatedWork W2002944732 @default.
- W1493707960 hasRelatedWork W2013175365 @default.
- W1493707960 hasRelatedWork W2024208090 @default.
- W1493707960 hasRelatedWork W2035666205 @default.
- W1493707960 hasRelatedWork W2039983382 @default.
- W1493707960 hasRelatedWork W2068810457 @default.
- W1493707960 hasRelatedWork W3094630037 @default.
- W1493707960 hasVolume "154" @default.
- W1493707960 isParatext "false" @default.
- W1493707960 isRetracted "false" @default.
- W1493707960 magId "1493707960" @default.
- W1493707960 workType "article" @default.