Matches in SemOpenAlex for { <https://semopenalex.org/work/W149397003> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W149397003 abstract "Abstract : The ultimate goal of the research is to develop new treatment reagents for metastatic prostate cancer. Unfortunately, treatment of metastatic prostate cancer is problematic as the cells can become resistant to the therapy being used. Therefore, this exploratory research was directed at developing new therapy reagents that will not be affected by changes within cells. The therapy reagents use a radioactive material, Auger electron emitting radionuclides, to help solve the problem. Auger emission is quite different from emission from other radioactive materials as they have short-range electron emissions that are very toxic to cells and are not affected by other biological factors. Importantly, the very short particle range can greatly decrease the toxicity outside of the cells that it is targeted to. The studies focused primarily on the synthesis of a peptide nucleic acid (PNA) that has an Auger-emitter (1-125) incorporated. By design the PNA Will bind with mRNA and DNA associated with insulin-like growth factor receptor that is upregulated on PC-3 prostate cancer cells. The first objective was to obtain a thymine analog, an iodouracil-amino acid for incorporating into a PNA. This was accomplished in 8 synthetic steps. However, the tri-n-butylstannyluracil-amino acid required to couple with the PNA could not be prepared in the same manner. Therefore, a second synthetic route was undertaken which proved to be successful. The iodouracilamino acid derivative and tri-n-butylstannyluracil amino acid derivative were coupled with a free amine on the PNA to form new PNA molecules (iodouracil conjugate was used as standard for radioiodinated derivative). The stannyl-PNA was readily radioiodinated to give the desired 125iodo-PNA. To obtain selective targeting to PC-3 prostate cancer cells and cause internalization of the PNA, the peptide bombesin was coupled to the PNA. Because the PNA have very low solubility in water, a polyethyleneglycol (PEG) linker was used." @default.
- W149397003 created "2016-06-24" @default.
- W149397003 creator A5068365998 @default.
- W149397003 date "2005-02-01" @default.
- W149397003 modified "2023-09-23" @default.
- W149397003 title "In Vitro Assessment of a Peptide Nucleic Acid (PNA) - Peptide Conjugate Labeled With an Auger-Emitting Radionuclide for Prostate Cell Killing" @default.
- W149397003 doi "https://doi.org/10.21236/ada435102" @default.
- W149397003 hasPublicationYear "2005" @default.
- W149397003 type Work @default.
- W149397003 sameAs 149397003 @default.
- W149397003 citedByCount "0" @default.
- W149397003 crossrefType "report" @default.
- W149397003 hasAuthorship W149397003A5068365998 @default.
- W149397003 hasConcept C121608353 @default.
- W149397003 hasConcept C126322002 @default.
- W149397003 hasConcept C134306372 @default.
- W149397003 hasConcept C185592680 @default.
- W149397003 hasConcept C197336794 @default.
- W149397003 hasConcept C21951064 @default.
- W149397003 hasConcept C24107716 @default.
- W149397003 hasConcept C2777343594 @default.
- W149397003 hasConcept C2779281246 @default.
- W149397003 hasConcept C2780192828 @default.
- W149397003 hasConcept C2989005 @default.
- W149397003 hasConcept C2993559085 @default.
- W149397003 hasConcept C33923547 @default.
- W149397003 hasConcept C502942594 @default.
- W149397003 hasConcept C55493867 @default.
- W149397003 hasConcept C71924100 @default.
- W149397003 hasConcept C86803240 @default.
- W149397003 hasConceptScore W149397003C121608353 @default.
- W149397003 hasConceptScore W149397003C126322002 @default.
- W149397003 hasConceptScore W149397003C134306372 @default.
- W149397003 hasConceptScore W149397003C185592680 @default.
- W149397003 hasConceptScore W149397003C197336794 @default.
- W149397003 hasConceptScore W149397003C21951064 @default.
- W149397003 hasConceptScore W149397003C24107716 @default.
- W149397003 hasConceptScore W149397003C2777343594 @default.
- W149397003 hasConceptScore W149397003C2779281246 @default.
- W149397003 hasConceptScore W149397003C2780192828 @default.
- W149397003 hasConceptScore W149397003C2989005 @default.
- W149397003 hasConceptScore W149397003C2993559085 @default.
- W149397003 hasConceptScore W149397003C33923547 @default.
- W149397003 hasConceptScore W149397003C502942594 @default.
- W149397003 hasConceptScore W149397003C55493867 @default.
- W149397003 hasConceptScore W149397003C71924100 @default.
- W149397003 hasConceptScore W149397003C86803240 @default.
- W149397003 hasLocation W1493970031 @default.
- W149397003 hasOpenAccess W149397003 @default.
- W149397003 hasPrimaryLocation W1493970031 @default.
- W149397003 hasRelatedWork W1973076932 @default.
- W149397003 hasRelatedWork W1988286575 @default.
- W149397003 hasRelatedWork W2024489056 @default.
- W149397003 hasRelatedWork W2085872254 @default.
- W149397003 hasRelatedWork W2087213851 @default.
- W149397003 hasRelatedWork W2103902942 @default.
- W149397003 hasRelatedWork W2326881153 @default.
- W149397003 hasRelatedWork W2585885920 @default.
- W149397003 hasRelatedWork W3123990725 @default.
- W149397003 hasRelatedWork W2461687825 @default.
- W149397003 isParatext "false" @default.
- W149397003 isRetracted "false" @default.
- W149397003 magId "149397003" @default.
- W149397003 workType "report" @default.