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- W1494171382 abstract "This chapter reviews the solubilization and reconstitution of the vesicular glutamate transport system and describes an extension of these techniques, resulting in a partial purification of the vesicular glutamate transport system and a partial separation of the glutamate transporter and proton-pump ATPase. As these techniques require a minimum of 10–20 mg synaptic vesicle protein, the chapter discusses the synaptic vesicle purification protocol for large-scale preparation of vesicles. The synaptic vesicle glutamate transport system performs a key function in neurotransmission by loading the synaptic vesicle with glutamate. Given its vital role in glutamate neurotransmission, directing glutamate to the neurotransmitter pathway away from the metabolic pathway, it potentially represents an important site of regulation of central nervous system pathogenesis. Synaptic vesicle glutamate transport requires a proton ATPase of the vacuolar type and chloride. These function to provide the appropriate intravesicular pH and electrochemical gradients that are necessary to drive glutamate transport. It is not known whether chloride stimulated, ATP-dependent glutamate transport is accomplished by several proteins, each functioning independently, or if more than one function is performed by one protein." @default.
- W1494171382 created "2016-06-24" @default.
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- W1494171382 date "1998-01-01" @default.
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- W1494171382 title "[9] Solubilization and reconstitution of synaptic vesicle glutamate transport system" @default.
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- W1494171382 doi "https://doi.org/10.1016/s0076-6879(98)96011-6" @default.
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