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• W1494251237 abstract "Background and Purpose The purpose of this study was to assess cerebral perfusion changes following systemic administration of the recreational drug 3,4‐methylendioxymethamphetamine ( MDMA ‘ecstasy’) to rats. Experimental Approach Cerebral perfusion was quantified using bolus‐tracking arterial spin labelling ( btASL ) MRI . Rats received MDMA (20 mg·kg −1 ; i.p.) and were assessed 1, 3 or 24 h later. Rats received MDMA (5 or 20 mg·kg −1 ; i.p.) and were assessed 3 h later. In addition, rats received MDMA (5 or 10 mg·kg −1 ; i.p.) or saline four times daily over 2 consecutive days and were assessed 8 weeks later. Perfusion‐weighted images were generated in a 7 tesla (7T) MRI scanner and experimental data was fitted to a quantitative model of cerebral perfusion to generate mean transit time ( MTT ), capillary transit time ( CTT ) and signal amplitude. Key Results MDMA reduces MTT and CTT and increases amplitude in somatosensory and motor cortex 1 and 3 h following administration, indicative of an increase in perfusion. Prior exposure to MDMA provoked a long‐term reduction in cortical 5‐ HT concentration, but did not produce a sustained effect on cerebral cortical perfusion. The response to acute MDMA challenge (20 mg·kg −1 ; i.p.) was attenuated in these animals indicating adaptation in response to prior MDMA exposure. Conclusions and Implications MDMA provokes changes in cortical perfusion, which are quantifiable by btASL MRI , a neuroimaging tool with translational potential. Future studies are directed towards elucidation of the mechanisms involved and correlating changes in cerebrovascular function with potential behavioural deficits associated with drug use." @default.
• W1494251237 created "2016-06-24" @default.
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• W1494251237 date "2013-06-12" @default.
• W1494251237 modified "2023-10-17" @default.
• W1494251237 title "MDMA ‘ecstasy’ increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI" @default.
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• W1494251237 doi "https://doi.org/10.1111/bph.12178" @default.
• W1494251237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3696322" @default.
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